Current perspectives on the mechanism of action of artemisinins (Q22061943)

Europe PubMed Central

title

Current perspectives on the mechanism of action of artemisinins (English)

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Jacob Golenser

1

Jacob

Golenser

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7 February 2023

Judith H. Waknine

2

Judith H

Waknine

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7 February 2023

Miriam Krugliak

3

Miriam

Krugliak

1 reference

7 February 2023

Nicholas H. Hunt

4

Nicholas H

Hunt

1 reference

7 February 2023

Georges E. Grau

5

Georges E

Grau

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International Journal for Parasitology

7 February 2023

language of work or name

English

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publication date

December 2006

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published in

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volume

36

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issue

14

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page(s)

1427-1441

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cites work

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Stage-specific gametocytocidal effect in vitro of the antimalaria drug qinghaosu on Plasmodium falciparum

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Establishment of an in vitro screening model for neurodegeneration induced by antimalarial drugs of the artemisinin-type.

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Antimalarial dihydroartemisinin also inhibits angiogenesis

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Alteration of biomass and artemisinin production in Artemisia annua hairy roots by media sterilization method and sugars

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Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media

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Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro

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Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

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Public health impact of drug resistant Plasmodium falciparum malaria

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Three-dimensional structure of Plasmodium falciparum Ca2+ -ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6.

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Artemisinins: mechanisms of action and potential for resistance

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Evidence that haem iron in the malaria parasite is not needed for the antimalarial effects of artemisinin

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Conventional and experimental treatment of cerebral malaria.

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Immunopathogenesis of cerebral malaria.

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Immunosuppressive activity of a molecule isolated from Artemisia annua on DTH responses compared with cyclosporin A.

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Characterization of noncovalent complexes of antimalarial agents of the artemisinin-type and FE(III)-heme by electrospray mass spectrometry and collisional activation tandem mass spectrometry

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Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs

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7 January 2021

Artemisinins: activities and actions

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Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistance

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7 January 2021

Artemisinin resistance: how can we find it?

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Effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos in vitro

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7 January 2021

Artemisinin derivatives: toxic for laboratory animals, safe for humans?

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7 January 2021

Response to: artemisinin derivatives: toxic for laboratory animals, safe for humans?

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7 January 2021

Apoptosis of human umbilical vein endothelial cells induced by artesunate

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7 January 2021

In vitro susceptibility of Plasmodium falciparum isolates in Vietnam to artemisinin derivatives and other antimalarials

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7 January 2021

Artemisinin induces omeprazole metabolism in human beings

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7 January 2021

Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

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7 January 2021

Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine

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7 January 2021

Changes in susceptibility of Plasmodium falciparum to artesunate in vitro in Yunnan Province, China

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7 January 2021

Two patients with falciparum malaria and poor in vivo responses to artesunate

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7 January 2021

Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

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7 January 2021

Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.

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7 January 2021

Effects of artemisinin derivatives on malaria transmissibility

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7 January 2021

Artemisinin and its derivatives: an important new class of antimalarial agents

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7 January 2021

Angiogenic proteins in brains of patients who died with cerebral malaria

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7 January 2021

Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication

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7 January 2021

Molecular docking and 3-D-QSAR studies on the possible antimalarial mechanism of artemisinin analogues

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7 January 2021

Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro

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7 January 2021

Possible modes of action of the artemisinin-type compounds.

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7 January 2021

Effects of endotoxin and dexamethasone on cerebral malaria in mice

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7 January 2021

Effects of qinghaosu (artemisinin) and its derivatives on experimental cutaneous leishmaniasis.

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7 January 2021

Breakdown of the blood-brain barrier in murine cerebral malaria

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7 January 2021

The multiple roles of the mitochondrion of the malarial parasite

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7 January 2021

Mathematical modelling of the chemotherapy of Plasmodium falciparum malaria with artesunate: postulation of 'dormancy', a partial cytostatic effect of the drug, and its implication for treatment regimens

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7 January 2021

Structure-activity relationships of the antimalarial agent artemisinin. 1. Synthesis and comparative molecular field analysis of C-9 analogs of artemisinin and 10-deoxoartemisinin

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Structure-activity relationships of the antimalarial agent artemisinin. 6. The development of predictive in vitro potency models using CoMFA and HQSAR methodologies

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7 January 2021

Structure-activity relationships of the antimalarial agent artemisinin. 7. Direct modification of (+)-artemisinin and in vivo antimalarial screening of new, potential preclinical antimalarial candidates

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7 January 2021

Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria

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7 January 2021

Structure-activity relationships of the antimalarial agent artemisinin. 5. Analogs of 10-deoxoartemisinin substituted at C-3 and C-9

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

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7 January 2021

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

1 reference

7 January 2021

Artemisinins target the SERCA of Plasmodium falciparum

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

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7 January 2021

Immunological processes in malaria pathogenesis.

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7 January 2021

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins

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7 January 2021

Activators and target genes of Rel/NF-kappaB transcription factors

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7 January 2021

Testing of chelating agents and vitamins against lead toxicity using mammalian cell cultures

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7 January 2021

Reaction of artemisinin with haemoglobin: implications for antimalarial activity

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin

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7 January 2021

Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Seasonal variations of Artemisinin and its biosynthetic precursors in tetraploid Artemisia annua plants compared with the diploid wild-type

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production

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7 January 2021

The antimalarial drug artemisinin alkylates heme in infected mice

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

The Plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Apparent drug failure following artesunate treatment of Plasmodium falciparum malaria in Freetown, Sierra Leone: four case reports

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7 January 2021

The chemotherapy of rodent malaria. LVI. Studies on the development of resistance to natural and synthetic endoperoxides

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7 January 2021

Artesunate reduces but does not prevent posttreatment transmission of Plasmodium falciparum to Anopheles gambiae.

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7 January 2021

Artemisinin antimalarials in pregnancy: a prospective treatment study of 539 episodes of multidrug-resistant Plasmodium falciparum

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7 January 2021

Comparative genomic and phylogenetic analyses of calcium ATPases and calcium-regulated proteins in the apicomplexa

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7 January 2021

A luminescence method for the quantitative determination of phagocytosis of erythrocytes, of malaria-parasitized erythrocytes and of malarial pigment

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Mechanisms of artemisinin resistance in the rodent malaria pathogen Plasmodium yoelii

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Carrier-mediated partitioning of artemisinin into Plasmodium falciparum-infected erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Neurotoxic mode of action of artemisinin

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Artemisinin Antimalarials Do Not Inhibit Hemozoin Formation

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Malaria parasites can develop stable resistance to artemisinin but lack mutations in candidate genes atp6 (encoding the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase), tctp, mdr1, and cg10.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

1 reference

7 January 2021

Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Iron chelators as drugs against malaria pose a potential risk.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

In-vivo therapeutic efficacy trial with artemisinin derivative, buparvaquone and imidocarb dipropionate against Babesia equi infection in donkeys

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Yeast model uncovers dual roles of mitochondria in action of artemisinin

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

The safety of antimalarial drugs in pregnancy

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

New trends in extraction, identification and quantification of artemisinin and its derivatives

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Induction and isolation of artemisinine-resistant mutants of Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Qinghaosu-induced changes in the morphology of Plasmodium inui.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Light microscopic changes in Plasmodium falciparum from Gabonese children treated with artemether.

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https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Neuropathologic toxicity of artemisinin derivatives in a mouse model.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

Association of failures of seven-day courses of artesunate in a non-immune population in Bangui, Central African Republic with decreased sensitivity of Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021

A case-control auditory evaluation of patients treated with artemether-lumefantrine.

1 reference

https://api.crossref.org/works/10.1016%2FJ.IJPARA.2006.07.011

7 January 2021