Metabolic actions of metformin in the heart can occur by AMPK-independent mechanisms (Q22241963)

7 February 2023

H. L. Parsons

2

Hannah L

Parsons

1 reference

7 February 2023

R. B. Wambolt

3

Richard B

Wambolt

1 reference

7 February 2023

K. Paulson

4

Kim

Paulson

1 reference

7 February 2023

V. Sharma

5

Vijay

Sharma

1 reference

7 February 2023

J. R. B. Dyck

6

Jason R B

Dyck

1 reference

7 February 2023

R. W. Brownsey

7

Roger W

Brownsey

1 reference

7 February 2023

M. F. Allard

8

Michael F

Allard

1 reference

American Journal of Physiology Heart and Circulatory Physiology

7 February 2023

language of work or name

English

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publication date

29 February 2008

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published in

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volume

294

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issue

6

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page(s)

H2497-H2506

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cites work

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Metformin and free fatty acid metabolism

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The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

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The AMP-activated protein kinase--fuel gauge of the mammalian cell?

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AMPK: a key sensor of fuel and energy status in skeletal muscle

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The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

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Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

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Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart

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Cellular mechanism of metformin action involves glucose transporter translocation from an intracellular pool to the plasma membrane in L6 muscle cells

21 January 2018

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The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

21 January 2018

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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Stimulation of hepatic glycogen synthesis by amino acids

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Metformin inhibits leptin secretion via a mitogen-activated protein kinase signalling pathway in brown adipocytes

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Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

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Characterization of 5'AMP-activated protein kinase activity in the heart and its role in inhibiting acetyl-CoA carboxylase during reperfusion following ischemia

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Metformin enhances insulin signalling in insulin-dependent and-independent pathways in insulin resistant muscle cells

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Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells

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Signaling pathways involved in human vascular smooth muscle cell proliferation and matrix metalloproteinase-2 expression induced by leptin: inhibitory effect of metformin.

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5-Aminoimidazole-4-carboxamide 1-beta -D-ribofuranoside (AICAR) stimulates myocardial glycogenolysis by allosteric mechanisms

21 January 2018

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Contraction-Induced Fatty Acid Translocase/CD36 Translocation in Rat Cardiac Myocytes Is Mediated Through AMP-Activated Protein Kinase Signaling

21 January 2018

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Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia

21 January 2018

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Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

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Modulation of L-type calcium channel expression during retinoic acid-induced differentiation of H9C2 cardiac cells.

21 January 2018

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Myocardial utilization of carbohydrate and lipids

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AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

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Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes

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Metabolic effects of metformin in non-insulin-dependent diabetes mellitus

21 January 2018

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The blooming of the French lilac

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Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase

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Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

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Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase

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Long-term metformin treatment stimulates cardiomyocyte glucose transport through an AMP-activated protein kinase-dependent reduction in GLUT4 endocytosis

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AMP-activated protein kinase: a key stress signaling pathway in the heart

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Metformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentration

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Role of AMP-activated protein kinase in mechanism of metformin action

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5-Aminoimidazole-4-Carboxamide-1- -D-Ribofuranoside and Metformin Inhibit Hepatic Glucose Phosphorylation by an AMP-Activated Protein Kinase-Independent Effect on Glucokinase Translocation

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Palmitate-mediated Alterations in the Fatty Acid Metabolism of Rat Neonatal Cardiac Myocytes

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7 January 2021

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7 January 2021

Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C

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7 January 2021

Functional role of AMP-activated protein kinase in the heart during exercise

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7 January 2021

Vasopressin-induced hypertrophy in H9c2 heart-derived myocytes

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7 January 2021

Phosphorylation control of cardiac acetyl-CoA carboxylase by cAMP-dependent protein kinase and 5'-AMP activated protein kinase

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7 January 2021

Metformin and the fate of fat

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7 January 2021

Neither LKB1 nor AMPK are the direct targets of metformin

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7 January 2021

Interleukin-1beta induction of mitogen-activated protein kinases in human mesangial cells. Role of oxidation

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7 January 2021

Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation

1 reference

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7 January 2021

Ethanol stimulates glucose uptake and translocation of GLUT-4 in H9c2 myotubes via a Ca(2+)-dependent mechanism

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7 January 2021

AMPK and metabolic adaptation by the heart to pressure overload

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7 January 2021

Carbohydrate and fatty acid metabolism of cultured adult cardiac myocytes

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7 January 2021

Contribution of oxidative metabolism and glycolysis to ATP production in hypertrophied hearts

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7 January 2021

Characterization of cardiac malonyl-CoA decarboxylase and its putative role in regulating fatty acid oxidation

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7 January 2021

Glycogen metabolism in the aerobic hypertrophied rat heart

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7 January 2021

Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities

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7 January 2021

10.1152/AJPHEART.00873.2007

Identifiers

DOI

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Fatcat ID

release_mifswlbtwjh3fhddphzfaelyk4

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