Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? (Q22251219)

7 February 2023

Stephen C. Cunnane

1

Stephen C

Cunnane

1 reference

7 February 2023

Raphael Chouinard-Watkins

series ordinal

2

author given names

Raphael

author last names

Chouinard-Watkins

1 reference

7 February 2023

Christian A. Castellano

series ordinal

3

author given names

Christian A

author last names

Castellano

1 reference

Prostaglandins, Leukotrienes and Essential Fatty Acids

7 February 2023

language of work or name

English

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publication date

January 2013

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published in

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volume

88

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issue

1

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page(s)

61-70

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cites work

Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Frequent amyloid deposition without significant cognitive impairment among the elderly

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Treatment of Alzheimer disease and prognosis of dementia: time to translate research to results.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Hippocampal atrophy and apolipoprotein E genotype are independently associated with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Lipid abnormalities in the brain in adult Down's syndrome and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Cognitive functions are not affected by dietary fatty acids in elderly subjects in the Pro.V.A. study population.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma omega-3 fatty acid response to a fish oil supplement in the healthy elderly

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Tin and fatty acids in dementia

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Experimental models and mechanisms underlying the protective effects of n-3 polyunsaturated fatty acids in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Investigation of postmortem brain polyunsaturated fatty acid composition in psychiatric disorders: limitations, challenges, and future directions

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

n-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Dietary ketosis enhances memory in mild cognitive impairment

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Brain fuel metabolism, aging, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Ethyl-EPA in Alzheimer's disease--a pilot study

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Omega-3 fatty acids, energy substrates, and brain function during aging

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Regulation of brain polyunsaturated fatty acid uptake and turnover

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Dietary reference intakes for DHA and EPA.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Omega-3 fatty acids and dementia.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism?

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Brain and systemic glucose metabolism in the healthy elderly following fish oil supplementation

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Are we consuming enough long chain omega-3 polyunsaturated fatty acids for optimal health?

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Fish, docosahexaenoic acid and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Linoleic- and linolenic acid dependency of some brain membrane-bound enzymes after lipid deprivation in rats

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Prevalence, incidence and duration of Braak's stages in the general population: can we know?

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Frequency of stages of Alzheimer-related lesions in different age categories

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Abnormal content of n-6 and n-3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Revising the definition of Alzheimer's disease: a new lexicon.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Age dependence of plasma phospholipid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma n-3 fatty acid response to an n-3 fatty acid supplement is modulated by apoE epsilon4 but not by the common PPAR-alpha L162V polymorphism in men.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Resolvins and protectins in inflammation resolution.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Effects of docosahexaenoic acid on mouse brain synaptic plasma membrane proteome analyzed by mass spectrometry and (16)O/(18)O labeling

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Regional membrane phospholipid alterations in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Administration of low doses of fish oil derived N-3 fatty acids to elderly subjects.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Glucose transport and utilization are altered in the brain of rats deficient in n-3 polyunsaturated fatty acids.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Recovery of brain docosahexaenoate leads to recovery of spatial task performance

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

[Relevance of metabolism of membrane phospholipids for Alzheimer dementia].

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Cognitive decline and fatty acid composition of erythrocyte membranes--The EVA Study

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n−3 fatty acids

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Distribution, interconversion, and dose response of n-3 fatty acids in humans

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma n-3 fatty acids and the risk of cognitive decline in older adults: the Atherosclerosis Risk in Communities Study

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Comparison between plasma and erythrocyte fatty acid content as biomarkers of fatty acid intake in US women

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Recovery of Rat Tissue Lipids from Essential Fatty Acid Deficiency: Brain, heart and testes

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Decrease and structural modifications of phosphatidylethanolamine plasmalogen in the brain with Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Moving forward with nutrition in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Rapid de-esterification and loss of eicosapentaenoic acid from rat brain phospholipids: an intracerebroventricular study

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Essentiality of omega 3 fatty acids: evidence from the primate model and implications for human nutrition

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

A comparison of the metabolism of eighteen-carbon 13C-unsaturated fatty acids in healthy women

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Imaging incorporation of circulating docosahexaenoic acid into the human brain using positron emission tomography

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Benefits of fatty fish on dementia risk are stronger for those without APOE epsilon4.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Restriction in complex activities of daily living in MCI: impact on outcome

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Dietary patterns and risk of dementia: the Three-City cohort study.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Red blood cell ω-3 fatty acid levels and markers of accelerated brain aging.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Cognitive and cardiovascular benefits of docosahexaenoic acid in aging and cognitive decline

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Dietary omega 3 polyunsaturated fatty acids and Alzheimer's disease: interaction with apolipoprotein E genotype

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Omega-3 fatty acids and risk of cognitive impairment and dementia

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Plasma and brain fatty acid profiles in mild cognitive impairment and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Associations between n-3 PUFA concentrations and cognitive function after recovery from late-life depression.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.

1 reference

https://api.crossref.org/works/10.1016%2FJ.PLEFA.2012.04.006

7 January 2021

10.1016/J.PLEFA.2012.04.006

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