Altered regulatory properties of human cardiac troponin I mutants that cause hypertrophic cardiomyopathy (Q22254076)

negative regulation of ATP-dependent activity

GOA release 2020-03-11

1 reference

hypertrophic cardiomyopathy

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

inferred from title

author

Hugh Christian Watkins

H Watkins

2

H

Watkins

1 reference

7 February 2023

K Elliott

1

K

Elliott

1 reference

7 February 2023

C S Redwood

series ordinal

3

author given names

C S

author last names

Redwood

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7 February 2023

language of work or name

English

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publication date

21 July 2000

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published in

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volume

275

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issue

29

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page(s)

22069-74

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cites work

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Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains

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A synthetic peptide mimics troponin I function in the calcium-dependent regulation of muscle contraction

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Properties of mutant contractile proteins that cause hypertrophic cardiomyopathy

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Coupling of calcium to the interaction of troponin I with troponin C from cardiac muscle

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A model structure of the muscle protein complex 4Ca2+.troponin C.troponin I derived from small-angle scattering data: implications for regulation.

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Stepwise subunit interaction changes by mono- and bisphosphorylation of cardiac troponin I.

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Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C

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Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

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Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: insights into disease pathogenesis and troponin function

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Distinct regions of troponin I regulate Ca2+-dependent activation and Ca2+ sensitivity of the acto-S1-TM ATPase activity of the thin filament

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Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain

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The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils

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Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy

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A Mutant Tropomyosin That Causes Hypertrophic Cardiomyopathy Is Expressed In Vivo and Associated With an Increased Calcium Sensitivity

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Familial hypertrophic cardiomyopathy: from mutations to functional defects

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Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury

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Investigation of a truncated cardiac troponin T that causes familial hypertrophic cardiomyopathy: Ca(2+) regulatory properties of reconstituted thin filaments depend on the ratio of mutant to wild-type protein

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7 January 2021