Folliculin (Q22675687)

Folliculin/SMCR8, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Folliculin, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Folliculin/SMCR8, tripartite DENN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

guanyl-nucleotide exchange factor activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

7 references

8 April 2019

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Identification and characterization of a novel folliculin-interacting protein FNIP2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

protein-containing complex binding

IPI

1 reference

8 April 2019

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

cell-cell contact zone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

1 reference

8 April 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

1 reference

8 April 2019

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

1 reference

8 April 2019

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

regulation of protein phosphorylation

TAS

biological process

1 reference

8 April 2019

Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of protein localization to nucleus

1 reference

8 April 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

regulation of cytokinesis

1 reference

8 April 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

positive regulation of autophagy

1 reference

8 April 2019

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of Rho protein signal transduction

1 reference

8 April 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of cell migration

1 reference

8 April 2019

Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

1 reference

8 April 2019

Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of cell growth

1 reference

8 April 2019

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

positive regulation of apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

positive regulation of cell adhesion

1 reference

8 April 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

positive regulation of transcription by RNA polymerase II

negative regulation of transcription by RNA polymerase II

2 references

27 March 2018

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

27 March 2018

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

in utero embryonic development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

positive regulation of protein phosphorylation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

cell-cell junction assembly

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of gene expression

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of mitochondrion organization

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of TOR signaling

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of TOR signaling

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

positive regulation of TOR signaling

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

regulation of histone acetylation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of protein kinase B signaling

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of ERK1 and ERK2 cascade

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of cell proliferation involved in kidney development

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

regulation of pro-B cell differentiation

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of ATP biosynthetic process

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8NFG4&geneProductId=UniProtKB:Q8NFG4

negative regulation of transcription by RNA polymerase II

3 references

8 April 2019

Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

mitochondrion organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

positive regulation of transforming growth factor beta receptor signaling pathway

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

8 April 2019

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of transcription, DNA-templated

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of cellular respiration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of mitochondrial DNA metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of muscle tissue development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

negative regulation of post-translational protein modification

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

positive regulation of intrinsic apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NFG4

has part(s)

Folliculin, C-terminal

1 reference

stated in

Folliculin/SMCR8, N-terminal

1 reference

stated in

Folliculin/SMCR8, tripartite DENN domain

1 reference

stated in