Noggin (Q22676651)

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mammalian protein found in Mus musculus

Nog
noggin

Language	Label	Description	Also known as
English	Noggin	mammalian protein found in Mus musculus	Nog noggin

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97466

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P97466

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

protein-containing complex binding

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

extracellular region

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

extracellular space

determination method

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

protein-containing complex

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

extracellular space

determination method

5 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

biological process

pattern specification process

determination method

1 reference

9 May 2019

Chordin and noggin promote organizing centers of forebrain development in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

axial mesoderm development

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

positive regulation of glomerulus development

determination method

1 reference

9 May 2019

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

skeletal system development

determination method

1 reference

9 May 2019

The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

cell differentiation

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

ureteric bud development

determination method

1 reference

9 May 2019

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

pituitary gland development

determination method

1 reference

9 May 2019

Noggin regulates Bmp4 activity during pituitary induction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

positive regulation of branching involved in ureteric bud morphogenesis

determination method

lung morphogenesis

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of cartilage development

determination method

1 reference

9 May 2019

Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

neural plate morphogenesis

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of cell differentiation

determination method

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

mesoderm formation

determination method

1 reference

9 May 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of apoptotic signaling pathway

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

cellular response to BMP stimulus

determination method

1 reference

9 May 2019

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

determination method

1 reference

9 May 2019

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

in utero embryonic development

determination method

1 reference

9 May 2019

Noggin regulates Bmp4 activity during pituitary induction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

BMP signaling pathway

determination method

1 reference

9 May 2019

Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of gene expression

determination method

1 reference

9 May 2019

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

somite development

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

determination method

1 reference

9 May 2019

Noggin is required for correct guidance of dorsal root ganglion axons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of BMP signaling pathway

determination method

9 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

24 April 2018

Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

regulation of BMP signaling pathway

determination method

1 reference

9 May 2019

Noggin regulates Bmp4 activity during pituitary induction

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

multicellular organism development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

prostatic bud formation

determination method

1 reference

9 May 2019

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

central nervous system development

determination method

1 reference

9 May 2019

The organizer factors Chordin and Noggin are required for mouse forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

neural tube closure

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

brain development

determination method

1 reference

9 May 2019

Chordin and noggin promote organizing centers of forebrain development in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

notochord morphogenesis

determination method

1 reference

9 May 2019

Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

cartilage development

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

osteoblast differentiation

determination method

1 reference

24 April 2018

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97466&geneProductId=UniProtKB:P97466

determination method

neural tube development

determination method

1 reference

9 May 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

spinal cord development

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

epithelial to mesenchymal transition

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

ureteric bud formation

determination method

1 reference

9 May 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

urogenital system development

determination method

1 reference

9 May 2019

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

endoderm formation

determination method

1 reference

9 May 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of cardiac muscle cell proliferation

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

motor neuron axon guidance

determination method

1 reference

9 May 2019

Noggin is required for correct guidance of dorsal root ganglion axons

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

face morphogenesis

determination method

1 reference

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

positive regulation of transcription by RNA polymerase II

determination method

3 references

9 May 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of pathway-restricted SMAD protein phosphorylation

determination method

outflow tract morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

ventricular compact myocardium morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

positive regulation of gene expression

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

atrial cardiac muscle tissue morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

heart trabecula morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

endocardial cushion morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

membranous septum morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

ventricular septum morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

pharyngeal arch artery morphogenesis

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

BMP signaling pathway involved in heart development

determination method

1 reference

9 May 2019

The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

endoderm development

determination method

1 reference

9 May 2019

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

positive regulation of cell population proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

visual learning

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

positive regulation of oligodendrocyte progenitor proliferation

determination method

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

negative regulation of BMP signaling pathway

determination method

10 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Brorin, a novel secreted bone morphogenetic protein antagonist, promotes neurogenesis in mouse neural precursor cells

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97466

determination method

dorsal/ventral pattern formation

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000061427

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000061427

Sitelinks

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