Caspase 10 (Q22679036)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

interleukin-1B-converting enzyme 2
caspase-10
FADD-like ICE2
FLICE2
ICE-like apoptotic protease 4
caspase 10, apoptosis-related cysteine protease
apoptotic protease MCH-4
caspase 10 apoptosis-related cysteine peptidase
CASP10
FAS-associated death domain protein interleukin-1B-converting enzyme 2
CASP-10

Language	Label	Description	Also known as
English	Caspase 10	mammalian protein found in Homo sapiens	interleukin-1B-converting enzyme 2 caspase-10 FADD-like ICE2 FLICE2 ICE-like apoptotic protease 4 caspase 10, apoptosis-related cysteine protease apoptotic protease MCH-4 caspase 10 apoptosis-related cysteine peptidase CASP10 FAS-associated death domain protein interleukin-1B-converting enzyme 2 CASP-10

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

caspase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Death-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Peptidase C14, caspase non-catalytic subunit p10, protein family

1 reference

based on heuristic

inferred from protein domain or family

Death effector domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase family C14A, cysteine active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C14, p20 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase C14A, caspase catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Peptidase family C14A, His active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

death effector domain binding

determination method

1 reference

8 April 2019

Caspase-10 is an initiator caspase in death receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

peptidase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

protein binding

determination method

10 references

8 April 2019

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Palmitoylation of CD95 facilitates formation of SDS-stable receptor aggregates that initiate apoptosis signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Control of autophagic cell death by caspase-10 in multiple myeloma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

RIOK3 interacts with caspase-10 and negatively regulates the NF-kappaB signaling pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

cysteine-type endopeptidase activity involved in execution phase of apoptosis

determination method

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92851&geneProductId=UniProtKB:Q92851

determination method

cysteine-type endopeptidase activity

determination method

4 references

8 April 2019

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

determination method

3 references

21 June 2018

Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92851&geneProductId=UniProtKB:Q92851

determination method

21 June 2018

Caspase-10 is an initiator caspase in death receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92851&geneProductId=UniProtKB:Q92851

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92851&geneProductId=UniProtKB:Q92851

determination method

cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

cysteine-type endopeptidase activity involved in apoptotic signaling pathway

determination method

4 references

8 April 2019

Caspase-10 is an initiator caspase in death receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

determination method

1 reference

8 April 2019

cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

CD95 death-inducing signaling complex

determination method

1 reference

8 April 2019

Caspase-10 is an initiator caspase in death receptor signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

biological process

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method

1 reference

8 April 2019

Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

apoptotic signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

determination method

2 references

execution phase of apoptosis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

apoptotic process

determination method

3 references

8 April 2019

Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

activation of cysteine-type endopeptidase activity involved in apoptotic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92851

determination method

physically interacts with

object has role

reaction inhibitor

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL197672

Peptidase family C14A, His active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Peptidase C14, p20 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Peptidase C14A, caspase catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Peptidase C14, caspase non-catalytic subunit p10

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Death effector domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Peptidase family C14A, cysteine active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92851

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000272879

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000272879

ENSP00000286186

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000286186

ENSP00000314599

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000314599

ENSP00000237865

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000237865

ENSP00000353250

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000353250

ENSP00000363781

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000363781

ENSP00000396835

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396835

ENSP00000401914

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401914

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q22679036&oldid=2023044579"