Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1 (Q24290112)

negative regulation of apoptotic process

GOA release 2020-03-11

1 reference

Apoptosis, caspase activation inhibitor

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

B N Chau

1

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E H Cheng

2

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D A Kerr

3

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J M Hardwick

The Bcl-2 protein family: arbiters of cell survival

4

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language of work or name

English

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publication date

July 2000

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published in

Molecular Cell

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volume

6

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issue

1

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page(s)

31-40

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caspase activation involves the formation of the aposome, a large (approximately 700 kDa) caspase-activating complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bax-independent inhibition of apoptosis by Bcl-XL.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Conversion of Bcl-2 to a Bax-like death effector by caspases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Modulation of cell death by Bcl-XL through caspase interaction

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Viral interference with apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Programmed cell death in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

The CARD domain: a new apoptotic signalling motif

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

RICK, a novel protein kinase containing a caspase recruitment domain, interacts with CLARP and regulates CD95-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Programmed cell death in animal development

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-2 and Bax function independently to regulate cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bc1-2 protects mice against fatal alphavirus encephalitis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Inhibition of virus-induced neuronal apoptosis by Bax.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

An induced proximity model for caspase-8 activation.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

1 reference

7 January 2021

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caspase-9 and APAF-1 form an active holoenzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caspases: intracellular signaling by proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Mitochondrial release of caspase-2 and -9 during the apoptotic process

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Molecular characterization of mitochondrial apoptosis-inducing factor

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

The murine gammaherpesvirus-68 M11 protein inhibits Fas- and TNF-induced apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Suicidal tendencies: apoptotic cell death by caspase family proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Autoproteolytic activation of pro-caspases by oligomerization

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Injected cytochrome c induces apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

1 reference

https://api.crossref.org/works/10.1016%2FS1097-2765%2805%2900021-3

7 January 2021

10.1016/S1097-2765(05)00021-3

Identifiers

DOI

1 reference

10.1016/S1097-2765(00)00005-8

4448014

1 reference

release_x45y5jr6g5ckrkf2ii7hibt7b4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/x45y5jr6g5ckrkf2ii7hibt7b4

24 November 2022

mapped directly with Wikidata item

4448014

1 reference

4448014

1 reference

PubMed publication ID

10949025

1 reference