The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH (Q24290444)

tripeptidyl-peptidase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

L Lin

1

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I Sohar

2

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H Lackland

3

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P Lobel

Journal of Biological Chemistry

4

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language of work or name

English

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publication date

19 January 2001

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published in

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volume

276

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page(s)

2249-55

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issue

3

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cites work

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

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Cloning and expression of an isovaleryl pepstatin-insensitive carboxyl proteinase gene from Xanthomonas sp. T-22.

21 January 2018

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Biochemical characterization of a lysosomal protease deficient in classical late infantile neuronal ceroid lipofuscinosis (LINCL) and development of an enzyme-based assay for diagnosis and exclusion of LINCL in human specimens and animal models

21 January 2018

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Purification and characterisation of a tripeptidyl aminopeptidase I from rat spleen.

21 January 2018

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Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I

21 January 2018

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Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis

21 January 2018

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Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis

21 January 2018

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Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis

21 January 2018

1 reference

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Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis

21 January 2018

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Purification and characterization of a tripeptidyl peptidase I from human osteoclastomas: evidence for its role in bone resorption

21 January 2018

1 reference

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Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitor

21 January 2018

1 reference

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Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium

21 January 2018

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[81] Organophosphorus compounds

21 January 2018

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Refined atomic model of wheat serine carboxypeptidase II at 2.2-A resolution

21 January 2018

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Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism

21 January 2018

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Families of serine peptidases.

21 January 2018

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Mutational analysis of the defective protease in classic late-infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disorder

21 January 2018

1 reference

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Partial purification and characterization of an ovarian tripeptidyl peptidase: a lysosomal exopeptidase that sequentially releases collagen-related (Gly-Pro-X) triplets

21 January 2018

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identification of catalytic residues of pepstatin-insensitive carboxyl proteinases from prokaryotes by site-directed mutagenesis

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identification of carboxyl residues in pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. 101 that participate in catalysis and substrate binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M008562200