Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N (Q24290689)

phosphatidylinositol 3-kinase regulator activity

GOA release 2020-03-11

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GOA release 2020-03-11

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K J Hurt

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Solomon Halbert Snyder

9

object named as

S H Snyder

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author name string

K Ye

1

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F Y Wu

3

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M Fang

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H R Luo

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J J Hong

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S Blackshaw

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C D Ferris

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

8

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language of work or name

English

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publication date

8 December 2000

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published in

Cell

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volume

103

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issue

6

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page(s)

919-30

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cites work

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Src, ras, and rac mediate the migratory response elicited by NGF and PMA in PC12 cells

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The selective and inducible activation of endogenous PI 3-kinase in PC12 cells results in efficient NGF-mediated survival but defective neurite outgrowth

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

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Neurite outgrowth in PC12 cells deficient in GAP-43

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Developmental expression pattern of phototransduction components in mammalian pineal implies a light-sensing function.

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Intact Ras function is required for sustained activation and nuclear translocation of extracellular signal-regulated kinases in nerve growth factor-stimulated PC12 cells

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Oncogenes and signal transduction

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Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis

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Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling.

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High Affinity Binding of Inositol Phosphates and Phosphoinositides to the Pleckstrin Homology Domain of RAC/Protein Kinase B and Their Influence on Kinase Activity

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Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

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Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

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Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

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Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity

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Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. Use of Cre/loxP recombination system

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Recent insights in phosphatidylinositol signaling

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Phosphatidylinositol 3-Kinase in HL-60 Nuclei Is Bound to the Nuclear Matrix and Increases During Granulocytic Differentiation

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Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene.

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Phospholipase C-gamma and phosphoinositide 3-kinase mediate cytoplasmic signaling in nerve growth cone guidance.

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Increase in nuclear phosphatidylinositol 3-kinase activity and phosphatidylinositol (3,4,5) trisphosphate synthesis precede PKC-zeta translocation to the nucleus of NGF-treated PC12 cells

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Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains

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Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

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Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

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Redistribution of the nuclear mitotic apparatus protein (NuMA) during mitosis and nuclear assembly. Properties of purified NuMA protein

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

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Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

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Membrane depolarization and calcium influx stimulate MEK and MAP kinase via activation of Ras.

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Cyclin D1 expression mediated by phosphatidylinositol 3-kinase through mTOR-p70(S6K)-independent signaling in growth factor-stimulated NIH 3T3 fibroblasts

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