Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP (Q24290701)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0044713

Gene Ontology release 2020-05-02

1 reference

GOA release 2020-03-11

ATP diphosphatase activity

1 reference

GOA release 2020-03-11

author name string

K Fujikawa

1

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H Kamiya

2

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H Yakushiji

3

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Y Nakabeppu

4

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H Kasai

Functional significance of the conserved residues for the 23-residue module among MTH1 and MutT family proteins

5

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language of work or name

English

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publication date

15 January 2001

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published in

Nucleic Acids Research

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volume

29

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issue

2

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page(s)

449-54

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Oxidants, antioxidants, and the degenerative diseases of aging

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

The unusual mutagenic specificity of an E. Coli mutator gene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: sanitization of nucleotide pool

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Polynucleotides. 33. Synthesis and properties of the dinucleoside monophosphates containing adenine S-cyclonucleosides and adenosine. Factors determining the stability and handedness of the stacking conformation in a dinucleoside monophosphate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

The kinetics of effector binding to phosphofructokinase. The allosteric conformational transition induced by 1,N6-ethenoadenosine triphosphate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

External ATP and its analogs activate the cystic fibrosis transmembrane conductance regulator by a cyclic AMP-independent mechanism.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Formation of 2-hydroxydeoxyadenosine triphosphate, an oxidatively damaged nucleotide, and its incorporation by DNA polymerases. Steady-state kinetics of the incorporation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Biochemical and physicochemical characterization of normal and variant forms of human MTH1 protein with antimutagenic activity.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=29672

Metabolic fate of oxidized guanine ribonucleotides in mammalian cells

29 November 2018

1 reference

12 December 2020

Induction of chromosomal gene mutations in Escherichia coli by direct incorporation of oxidatively damaged nucleotides. New evaluation method for mutagenesis by damaged DNA precursors in vivo

1 reference

12 December 2020

Synthesis of 8-Hydroxypurine Nucleosides

1 reference

12 December 2020

Mouse neuroblastoma adenylate cyclase. Adenosine and adenosine analogues as potent effectors of adenylate cyclase activity

1 reference

12 December 2020

Selective expansion of mitochondrial nucleoside triphosphate pools in antimetabolite-treated HeLa cells

1 reference

12 December 2020

[Effect of 8-Br-ATP and 8-Oxy-ATP on RNA synthesis by RNA polymerase from Escherichia coli]

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/29.2.449

1 reference

3110948

3110948

1 reference

1 reference

1 reference