Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein (Q24291950)

protein homodimerization activity

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Complement component 3

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Complement receptor type 2

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2

V M Holers

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Susan A. Boackle

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object named as

S A Boackle

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author name string

X Chen

3

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G Szakonyi

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D R Karp

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E K Wakeland

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L Morel

Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

7

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language of work or name

English

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publication date

November 2001

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published in

Immunity

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volume

15

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issue

5

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page(s)

775-85

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cites work

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CD21 augments antigen presentation in immune individuals

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Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface

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Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2

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Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

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Antibody response to a T-dependent antigen requires B cell expression of complement receptors

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C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

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Proliferation of resting B cells is modulated by CR2 and CR1

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The genetics of human systemic lupus erythematosus

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Co-ligation of mouse complement receptors 1 and 2 with surface IgM rescues splenic B cells and WEHI-231 cells from anti-surface IgM-induced apoptosis

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Antibodies as antigens. The use of mouse monoclonal antibodies to focus human T cells against selected targets.

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T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE)

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Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse

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Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function

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Complement receptor expression and activation of the complement cascade on B lymphocytes from patients with systemic lupus erythematosus (SLE)

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Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes

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Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

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Polygenic control of susceptibility to murine systemic lupus erythematosus

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Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain

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Epistatic modifiers of autoimmunity in a murine model of lupus nephritis

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Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.

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Complement dependence of localisation of aggregated IgG in germinal centres

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Ligand specificities of mouse complement receptor types 1 (CR1) and 2 (CR2) purified from spleen cells

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A critical role for complement in maintenance of self-tolerance

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Structure of complement receptor 2 in complex with its C3d ligand

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Genetic dissection of systemic lupus erythematosus

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Decreased expression of the C3b/C4b receptor (CR1) and the C3d receptor (CR2) on B lymphocytes and of CR1 on neutrophils of patients with systemic lupus erythematosus

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Impaired affinity maturation in Cr2-/- mice is rescued by adjuvants without improvement in germinal center development.

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