RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia (Q24292406)

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7 December 2019

title

RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia (English)

1 reference

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RAS guanyl releasing protein 4

7 December 2019

main subject

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positive regulation of Ras protein signal transduction

GOA release 2020-03-11

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GOA release 2020-03-11

leukemia

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based on heuristic

inferred from title

acute myeloid leukemia

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3

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7 December 2019

6

Channing J Der

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7 December 2019

author name string

Gary W Reuther

1

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7 December 2019

Que T Lambert

2

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7 December 2019

Michael A Caligiuri

4

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7 December 2019

Lawrence A Quilliam

5

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7 December 2019

language of work or name

English

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publication date

5 March 2002

1 reference

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Journal of Biological Chemistry

7 December 2019

published in

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7 December 2019

volume

277

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7 December 2019

page(s)

30508-30514

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7 December 2019

issue

34

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Oncogenic transcription factors in the human acute leukemias

7 December 2019

cites work

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Expression cloning of oncogenes by retroviral transfer of cDNA libraries

21 January 2018

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Identification and characterization of an activating TrkA deletion mutation in acute myeloid leukemia

21 January 2018

1 reference

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A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

21 January 2018

1 reference

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The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13

21 January 2018

1 reference

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Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor

21 January 2018

1 reference

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Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral

21 January 2018

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Biological assays for Ras transformation

21 January 2018

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Cell cycle-dependent activation of Ras.

21 January 2018

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Analysis of Ras protein expression in mammalian cells

21 January 2018

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Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

21 January 2018

1 reference

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Regulation of RasGRP via a phorbol ester-responsive C1 domain.

21 January 2018

1 reference

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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs

21 January 2018

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A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

21 January 2018

1 reference

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CalDAG-GEFIII activation of Ras, R-ras, and Rap1.

21 January 2018

1 reference

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Activation of the Rap1 guanine nucleotide exchange gene, CalDAG-GEF I, in BXH-2 murine myeloid leukemia

21 January 2018

1 reference

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RasGRP is essential for mouse thymocyte differentiation and TCR signaling

21 January 2018

1 reference

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The Ras branch of small GTPases: Ras family members don't fall far from the tree

21 January 2018

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Measurement of GTP-bound Ras-like GTPases by activation-specific probes

21 January 2018

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111330200

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

21 January 2018

1 reference

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Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines

21 January 2018

1 reference

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Mammalian phosphoinositide-specific phospholipase C.

21 January 2018

1 reference

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Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis

21 January 2018

1 reference

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A novel Cdc42Hs mutant induces cellular transformation

21 January 2018

1 reference

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21 January 2018

Hematologic malignancies

1 reference

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Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M111330200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11880369%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1 reference