MgF(3)(-) as a transition state analog of phosphoryl transfer (Q24292944)

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Stephen J Smerdon

object named as

Stephen J Smerdon

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author name string

Debbie L Graham

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Peter N Lowe

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Geoffrey W Grime

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Michael Marsh

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John F Eccleston

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride

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language of work or name

English

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publication date

March 2002

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published in

Chemistry and Biology

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volume

9

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issue

3

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page(s)

375-81

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cites work

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Ternary hydroxide complexes in neutral solutions of Al3+ and F-.

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Fluoroaluminates activate transducin-GDP by mimicking the gamma-phosphate of GTP in its binding site

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Ras-catalyzed hydrolysis of GTP: a new perspective from model studies

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AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

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Structures of active conformations of UMP kinase from Dictyostelium discoideum suggest phosphoryl transfer is associative

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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

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Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

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GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4

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Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

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X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-

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Structure at 1.65 A of RhoA and its GTPase-activating protein in complex with a transition-state analogue

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A novel magnesium-dependent mechanism for the activation of transducin by fluoride

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Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride

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Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins

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Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP

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Leaving no element of doubt: analysis of proteins using microPIXE.

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Equilibrium and kinetic study of the conformational transition toward the active state of p21Ha-ras, induced by the binding of BeF3- to the GDP-bound state, in the absence of GTPase-activating proteins

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pH influences fluoride coordination number of the AlFx phosphoryl transfer transition state analog

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Processing of X-ray diffraction data collected in oscillation mode

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