Increased gamma-globin expression in a nondeletion HPFH mediated by an erythroid-specific DNA-binding factor (Q24293074)

positive regulation of transcription by RNA polymerase II

GOA release 2020-03-11

1 reference

K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

GOA release 2020-03-11

author name string

D I Martin

series ordinal

1

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S F Tsai

series ordinal

2

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S H Orkin

series ordinal

3

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language of work or name

English

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publication date

30 March 1989

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published in

Nature

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volume

338

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issue

6214

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page(s)

435-8

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cites work

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A distant enhancer element is required for polymerase III transcription of a U6 RNA gene

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Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene

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In vitro binding of cell-specific and ubiquitous nuclear proteins to the octamer motif of the SV40 enhancer and related motifs present in other promoters and enhancers

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Identification and purification of a human lymphoid-specific octamer-binding protein (OTF-2) that activates transcription of an immunoglobulin promoter in vitro

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A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes

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An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity

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An erythrocyte-specific DNA-binding factor recognizes a regulatory sequence common to all chicken globin genes

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A protein factor binding to an octamer motif in the gamma-globin promoter disappears upon induction of differentiation and hemoglobin synthesis in K562 cells

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Activation of the human beta-globin promoter in K562 cells by DNA sequences 5' to the fetal gamma- or embryonic zeta-globin genes

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Two distinct transcription factors bind to the HSV thymidine kinase promoter in vitro.

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Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7.

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The effects of HPFH mutations in the human gamma-globin promoter on binding of ubiquitous and erythroid specific nuclear factors

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A history of the human fetal globin gene duplication

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Human growth hormone as a reporter gene in regulation studies employing transient gene expression

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Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells

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7 January 2021

Nuclear proteins that bind the human gamma-globin gene promoter: alterations in binding produced by point mutations associated with hereditary persistence of fetal hemoglobin

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7 January 2021

G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene

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The human beta-globin gene 3' enhancer contains multiple binding sites for an erythroid-specific protein.

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Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

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A protein binds to a satellite DNA repeat at three specific sites that would be brought into mutual proximity by DNA folding in the nucleosome.

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7 January 2021

Several distinct "CCAAT" box binding proteins coexist in eukaryotic cells

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57 Sequencing end-labeled DNA with base-specific chemical cleavages

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