MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation (Q24294200)

2

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Colin D White

3

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David B Sacks

4

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Roland S Annan

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

29 April 2011

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published in

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volume

286

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page(s)

15010-21

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issue

17

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describes a project that uses

ImageQuant

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3083173/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling

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IQGAP proteins are integral components of cytoskeletal regulation

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Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

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IQGAP1 binds ERK2 and modulates its activity

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IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin

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IQGAP1 and calmodulin modulate E-cadherin function

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IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis

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IQGAP1 promotes cell proliferation and is involved in a phosphorylation-dependent manner in wound closure of bronchial epithelial cells.

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N-cadherin regulates cytoskeletally associated IQGAP1/ERK signaling and memory formation

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IQGAP1 binds Rap1 and modulates its activity

27 September 2017

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IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly

27 September 2017

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IQGAP1 in cellular signaling: bridging the GAP.

27 September 2017

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Self-association of IQGAP1: characterization and functional sequelae

27 September 2017

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27 September 2017

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Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.

27 September 2017

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Phosphorylation of IQGAP1 modulates its binding to Cdc42, revealing a new type of rho-GTPase regulator

27 September 2017

1 reference

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The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

27 September 2017

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IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton

27 September 2017

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KSR is a scaffold required for activation of the ERK/MAPK module

27 September 2017

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The EGF receptor family as targets for cancer therapy

27 September 2017

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The EGF receptor: a nexus for trafficking and signaling

27 September 2017

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c-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function

27 September 2017

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Mitogenic signaling from the egf receptor is attenuated by a phospholipase C-gamma/protein kinase C feedback mechanism

27 September 2017

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Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor

27 September 2017

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A negative feedback loop attenuates EGF-induced morphological changes

27 September 2017

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Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin

27 September 2017

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Protein kinase C isoenzymes, p53, accumulation of rhodamine 123, glutathione-S-transferase, topoisomerase II and MRP in multidrug resistant cell lines

27 September 2017

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c-Src phosphorylates epidermal growth factor receptor on tyrosine 845.

27 September 2017

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IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway

27 September 2017

1 reference

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Direct analysis and identification of proteins in mixtures by LC/MS/MS and database searching at the low-femtomole level.

30 May 2018

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Role of mitogen-activated protein kinase kinase in regulation of the epidermal growth factor receptor by protein kinase C.

30 May 2018

1 reference

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Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3083173

IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.

30 May 2018

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Crossref

https://api.crossref.org/works/10.1074%2FJBC.M111.227694

The juxtamembrane region of EGFR takes center stage.

21 January 2018

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Evidence for discrete diacylglycerol and phorbol ester activator sites on protein kinase C. Differences in effects of 1-alkanol inhibition, activation by phosphatidylethanolamine and calcium chelation.

21 January 2018

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IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling

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The EGF receptor: a nexus for trafficking and signaling

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https://api.crossref.org/works/10.1074%2FJBC.M111.227694