Siah-1 facilitates ubiquitination and degradation of synphilin-1 (Q24295130)

regulation of neurotransmitter secretion

GOA release 2020-03-11

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GOA release 2020-03-11

protein ubiquitination

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7

Nobutaka Hattori

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Yoshikuni Mizuno

8

object named as

Yoshikuni Mizuno

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Masayasu Matsumoto

10

object named as

Masayasu Matsumoto

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author name string

Yoshito Nagano

1

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Hiroshi Yamashita

2

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Tetsuya Takahashi

3

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Shosei Kishida

4

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Takeshi Nakamura

5

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Eizo Iseki

6

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Akira Kikuchi

Journal of Biological Chemistry

9

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language of work or name

English

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publication date

19 December 2003

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published in

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volume

278

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issue

51

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page(s)

51504-14

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cites work

Synphilin-1 is present in Lewy bodies in Parkinson's disease

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Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125.

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7 January 2021

Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.

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7 January 2021

Characterization of human homologs of the Drosophila seven in absentia (sina) gene

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7 January 2021

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.

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7 January 2021

Tyrosine 125 of alpha-synuclein plays a critical role for dimerization following nitrative stress.

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7 January 2021

Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases

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7 January 2021

PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.

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https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

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7 January 2021

Lack of binding observed between human alpha-synuclein and Bcl-2 protein family

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7 January 2021

Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons

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7 January 2021

Inhibitory effect of MK-801 on amantadine-induced dopamine release in the rat striatum.

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7 January 2021

Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system

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7 January 2021

Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity

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https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein

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https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses

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https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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7 January 2021

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

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7 January 2021

Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

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7 January 2021

Alpha-synuclein in Lewy bodies

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7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

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7 January 2021

Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions

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7 January 2021

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

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7 January 2021

Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

A binding motif for Siah ubiquitin ligase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Siah-1 binds and regulates the function of Numb

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Regulation of synaptophysin degradation by mammalian homologues of seven in absentia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Synphilin-1 is developmentally localized to synaptic terminals, and its association with synaptic vesicles is modulated by alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Structural analysis of Siah1 and its interactions with Siah-interacting protein (SIP).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

The RING finger protein Siah-1 regulates the level of the transcriptional coactivator OBF-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Regulation of BOB.1/OBF.1 stability by SIAH

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Pathology and biology of the Lewy body

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Neuropathology of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Proteasomal regulation of nuclear receptor corepressor-mediated repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

The xeroderma pigmentosum group E gene product DDB2 is a specific target of cullin 4A in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021

A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M306347200

7 January 2021