Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1 (Q24296797)

negative regulation of transcription, DNA-templated

GOA release 2020-03-11

1 reference

Raymond Chuen-Chung Chang

GOA release 2020-03-11

author

5

object named as

Raymond Chuen-Chung Chang

Raymond Chuen-Chung

Chang

1 reference

30 October 2023

Kwok-Fai Lau

9

Kwok-Fai

Lau

1 reference

30 October 2023

Declan M McLoughlin

7

Declan M

McLoughlin

1 reference

30 October 2023

Hoi-Tin Yu

1

Hoi-Tin

Yu

1 reference

30 October 2023

William Wai-Lun Chan

2

William Wai-Lun

Chan

1 reference

30 October 2023

Ka-Ho Chai

3

Ka-Ho

Chai

1 reference

30 October 2023

Chris Wing-Cheung Lee

4

Chris Wing-Cheung

Lee

1 reference

30 October 2023

Man-Shan Yu

6

Man-Shan

Yu

1 reference

30 October 2023

Christopher C J Miller

8

Christopher C J

Journal of Cellular Biochemistry

Miller

1 reference

30 October 2023

language of work or name

English

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publication date

1 March 2010

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published in

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volume

109

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issue

4

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page(s)

782-93

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cites work

FE65 in Alzheimer's disease: neuronal distribution and association with neurofibrillary tangles

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

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Gonadotropin-mediated regulation of the murine VEGF expression in MA-10 Leydig cells

21 January 2018

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Sp1 and Sp3 regulate transcription of the cyclin-dependent kinase 5 regulatory subunit 2 (p39) promoter in neuronal cells

21 January 2018

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DNA-binding protein Pur alpha and transcription factor YY1 function as transcription activators of the neuron-specific FE65 gene promoter

21 January 2018

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Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer

21 January 2018

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7 January 2021

Sp1-mediated transcriptional activation is repressed by Sp3

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7 January 2021

The role of transcription factors Sp1 and YY1 in proximal promoter region in initiation of transcription of the mu opioid receptor gene in human lymphocytes

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7 January 2021

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

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7 January 2021

Isoform-specific knockout of FE65 leads to impaired learning and memory

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7 January 2021

The FE65 proteins and Alzheimer's disease

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7 January 2021

Transcription factor Sp1 dysregulation in Alzheimer's disease.

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7 January 2021

Alternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markers

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7 January 2021

Real-time PCR quantitation of FE65 a β-amyloid precursor protein-binding protein after traumatic brain injury in rats

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7 January 2021

The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type

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7 January 2021

Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene

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7 January 2021

Sp1: emerging roles--beyond constitutive activation of TATA-less housekeeping genes

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7 January 2021

Presenilin: running with scissors in the membrane

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7 January 2021

Sp transcription factor family and its role in cancer

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7 January 2021

Abnormal Sp1 transcription factor expression in Alzheimer disease and tauopathies

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7 January 2021

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

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7 January 2021

Mammalian SP/KLF transcription factors: bring in the family

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7 January 2021

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

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7 January 2021

Expression of the Fe65 adapter protein in adult and developing mouse brain.

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7 January 2021

The Sp-family of transcription factors

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7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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7 January 2021

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

1 reference

7 January 2021

Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.

1 reference

7 January 2021

Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus

1 reference

7 January 2021

Mutually exclusive interactions between factors binding to adjacent Sp1 and AT-rich elements regulate gastrin gene transcription in insulinoma cells

1 reference

7 January 2021

Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3

1 reference

7 January 2021

Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin

1 reference

7 January 2021

Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1.

1 reference

7 January 2021

Sp3 and Sp4 can repress transcription by competing with Sp1 for the core cis-elements on the human ADH5/FDH minimal promoter

1 reference

7 January 2021

Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

1 reference

7 January 2021

Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1.

1 reference

7 January 2021

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

1 reference

7 January 2021

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

1 reference

7 January 2021

Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.

1 reference

7 January 2021

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective

1 reference

7 January 2021

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.

1 reference

7 January 2021

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription

1 reference

7 January 2021

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

1 reference

7 January 2021

Identification of the positive regulatory and distinct core regions of promoters, and transcriptional regulation in three types of mouse phospholipid hydroperoxide glutathione peroxidase.

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7 January 2021

A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases

1 reference

7 January 2021

Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes

1 reference

7 January 2021

The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription

1 reference

7 January 2021

An upstream open reading frame impedes translation of the huntingtin gene

1 reference

7 January 2021

Translational regulation of BACE-1 expression in neuronal and non-neuronal cells

1 reference

7 January 2021

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

7 January 2021

The RNA polymerase II core promoter: a key component in the regulation of gene expression

1 reference

7 January 2021

Mutation of the feh-1 gene, the Caenorhabditis elegans orthologue of mammalian Fe65, decreases the expression of two acetylcholinesterase genes

1 reference

7 January 2021

Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.

1 reference

7 January 2021

The transcription factor Yin Yang 1 is an activator of BACE1 expression

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7 January 2021

The Yin and Yang of YY1 in the nervous system

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7 January 2021

Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.

1 reference

7 January 2021

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

1 reference

7 January 2021

Cellular transcription factors Sp1 and Sp3 suppress varicella-zoster virus origin-dependent DNA replication.

1 reference

7 January 2021

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

1 reference

7 January 2021

Upstream open reading frames as regulators of mRNA translation

1 reference

7 January 2021

Maximal induction of a subset of interferon target genes requires the chromatin-remodeling activity of the BAF complex

1 reference

7 January 2021

Gene regulation by Sp1 and Sp3.

1 reference

7 January 2021

Genetic regulation of glutamate receptor ion channels

1 reference

7 January 2021

Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.

1 reference

7 January 2021

Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors

1 reference

7 January 2021

Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells

1 reference

7 January 2021

The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.

1 reference

7 January 2021

Curcumin decreases specificity protein expression in bladder cancer cells

1 reference

7 January 2021

Isolation of cDNA fragments hybridizing to rat brain-specific mRNAs

1 reference

7 January 2021

Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivatives.

1 reference

7 January 2021

Mithramycin blocks protein binding and function of the SV40 early promoter

1 reference

7 January 2021

Mithramycin inhibits SP1 binding and selectively inhibits transcriptional activity of the dihydrofolate reductase gene in vitro and in vivo

1 reference

7 January 2021

Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases.

1 reference

7 January 2021

R5020 and RU486 act as progesterone receptor agonists to enhance Sp1/Sp4-dependent gene transcription by an indirect mechanism

1 reference

7 January 2021

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

7 January 2021

Sp1 is essential for p16 expression in human diploid fibroblasts during senescence

1 reference

7 January 2021