Megalin and cubilin: multifunctional endocytic receptors (Q24296807)

Europe PubMed Central

title

Megalin and cubilin: multifunctional endocytic receptors (English)

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main subject

Cubilin

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Nature Reviews Molecular Cell Biology

GOA release 2020-03-11

author name string

Erik Ilsø Christensen

series ordinal

1

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Henrik Birn

series ordinal

2

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language of work or name

English

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publication date

April 2002

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published in

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volume

3

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issue

4

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page(s)

256-66

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cites work

Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family

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Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

31 March 2020

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Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1)

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Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor

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A gene for a low density lipoprotein receptor-related protein in the nematode Caenorhabditis elegans

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Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region

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Lipoprotein receptors: new roles for ancient proteins.

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Identification of the second cluster of ligand-binding repeats in megalin as a site for receptor-ligand interactions

31 March 2020

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Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis

31 March 2020

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Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein

31 March 2020

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Identification of rat yolk sac target protein of teratogenic antibodies, gp280, as intrinsic factor-cobalamin receptor

31 March 2020

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The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin-binding peripheral membrane protein with homology to developmental proteins

31 March 2020

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The CUB domain. A widespread module in developmentally regulated proteins

31 March 2020

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Molecular Dissection of the Intrinsic Factor-Vitamin B12Receptor, Cubilin, Discloses Regions Important for Membrane Association and Ligand Binding

31 March 2020

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Interaction of model class A1, class A2, and class Y amphipathic helical peptides with membranes

31 March 2020

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The membrane association sequences of the prostaglandin endoperoxide synthases-1 and -2 isozymes

31 March 2020

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The membrane association domain of RGS16 contains unique amphipathic features that are conserved in RGS4 and RGS5

31 March 2020

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RGS4 binds to membranes through an amphipathic alpha -helix.

31 March 2020

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Effect of processing inhibitors on cobalamin (vitamin B12) transcytosis in polarized opossum kidney cells

31 March 2020

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Megalin- and cubilin-mediated endocytosis of protein-bound vitamins, lipids, and hormones in polarized epithelia

31 March 2020

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The intrinsic factor-vitamin B12 receptor, cubilin, is assembled into trimers via a coiled-coil alpha-helix

31 March 2020

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Identification and characterization of two distinct ligand binding regions of cubilin

31 March 2020

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The crystal structures of two spermadhesins reveal the CUB domain fold

31 March 2020

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The 2.4 Å resolution crystal structure of boar seminal plasma PSP-I/PSP-II: a zona pellucida-binding glycoprotein heterodimer of the spermadhesin family built by a CUB domain architecture

31 March 2020

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Cubilin and megalin expression and their interaction in the rat intestine: effect of thyroidectomy

31 March 2020

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Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein

31 March 2020

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Immunocytochemical localization of the intrinsic factor-cobalamin receptor in dog-ileum: distribution of intracellular receptor during cell maturation

31 March 2020

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The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border

31 March 2020

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Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies

31 March 2020

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Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP)

31 March 2020

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Monoclonal antibodies with exclusive reactivity against parathyroid cells and tubule cells of the kidney

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Expression of a cell surface antigen with potential Ca2+-sensor/receptor function in rat placenta and uterus

31 March 2020

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Ultrastructural localization of megalin in the rat cochlear duct

31 March 2020

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Microdomains of distinctive glycoprotein composition in the kidney proximal tubule brush border

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31 March 2020

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39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein

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Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo

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RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors

31 March 2020

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Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein

31 March 2020

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The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

31 March 2020

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Unusual processing of GP280, a protein associated with the intermicrovillar areas of yolk sac epithelial cells: plasma membrane delivery of immature protein

31 March 2020

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Cubilin expression and posttranslational modification in the canine gastrointestinal tract

31 March 2020

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Inherited selective intestinal cobalamin malabsorption and cobalamin deficiency in dogs

31 March 2020

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Functional characterization of rat gp600/megalin promoter: combination of proximal Sp1 site and JCV repeat is important in rat gp600/megalin promoter activation.

31 March 2020

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Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100

31 March 2020

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Regulation of gp330/megalin expression by vitamins A and D

31 March 2020

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Cubilin, the endocytic receptor for intrinsic factor-vitamin B(12) complex, mediates high-density lipoprotein holoparticle endocytosis

31 March 2020

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Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization

31 March 2020

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The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis.

31 March 2020

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ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.

31 March 2020

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HYPERPARATHYROIDISM IS ASSOCIATED WITH REDUCED EXPRESSION OF A PARATHYROID CALCIUM RECEPTOR MECHANISM DEFINED BY MONOCLONAL ANTIPARATHYROID ANTIBODIES

31 March 2020

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Defective forebrain development in mice lacking gp330/megalin

31 March 2020

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Megalin knockout mice as an animal model of low molecular weight proteinuria.

31 March 2020

1 reference

Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1

31 March 2020

1 reference

Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins

31 March 2020

1 reference

Specific association of megalin and the Na+/H+ exchanger isoform NHE3 in the proximal tubule

31 March 2020

1 reference

Megalin is essential for renal proximal tubule reabsorption and accumulation of transcobalamin-B(12).

31 March 2020

1 reference

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3

31 March 2020

1 reference

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

31 March 2020

1 reference

The free hormone hypothesis: a physiologically based mathematical model

31 March 2020

1 reference

Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia

31 March 2020

1 reference

Uptake and processing of 59Fe-labelled and 125I-labelled rat transferrin by early organogenesis rat conceptuses in vitro.

31 March 2020

1 reference

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

31 March 2020

1 reference

Inhibition of endosome fusion in primary hepatocytes prevents asialoglycoprotein degradation but not uptake of transferrin iron demonstrating that intracellular iron release occurs from early endosomes

31 March 2020

1 reference

A novel mammalian iron-regulated protein involved in intracellular iron metabolism

31 March 2020

1 reference

The role of protein traffic in the progression of renal diseases.

31 March 2020

1 reference

The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.

31 March 2020

1 reference

Role of megalin (gp330) in transcytosis of thyroglobulin by thyroid cells. A novel function in the control of thyroid hormone release

31 March 2020

1 reference

Role of thyroglobulin endocytic pathways in the control of thyroid hormone release

31 March 2020

1 reference

Megalin antagonizes activation of the parathyroid hormone receptor.

31 March 2020

1 reference

A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily

31 March 2020

1 reference

Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs

31 March 2020

1 reference

Megalin Deficiency Offers Protection from Renal Aminoglycoside Accumulation

31 March 2020

1 reference

Cellular signalling by lipoprotein receptors

31 March 2020

1 reference

Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin

31 March 2020

1 reference

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein

31 March 2020

1 reference

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2

31 March 2020

1 reference

Role of rap in the biogenesis of lipoprotein receptors

31 March 2020

1 reference

Lysosomal cobalamin accumulation in fibroblasts from a patient with an inborn error of cobalamin metabolism (cblF complementation group): visualization by electron microscope radioautography

31 March 2020

1 reference

Cubilin is an albumin binding protein important for renal tubular albumin reabsorption

31 March 2020

1 reference

Evidence for the Role of Megalin in Renal Uptake of Transthyretin

31 March 2020

1 reference

Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

31 March 2020

1 reference

beta2-glycoprotein-I (apolipoprotein H) and beta2-glycoprotein-I-phospholipid complex harbor a recognition site for the endocytic receptor megalin

31 March 2020

1 reference

Trichosanthin interacts with and enters cells via LDL receptor family members

31 March 2020

1 reference

A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney

31 March 2020

1 reference

gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex

31 March 2020

1 reference