Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity (Q24297286)

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Naoya Sakamoto

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Mina Nakagawa

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Sei Kakinuma

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Kako Mishima

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Akiko Kusano-Kitazume

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Kei Kiyohashi

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Miyako Murakawa

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Yuki Nishimura-Sakurai

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Seishin Azuma

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Megumi Tasaka-Fujita

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Yasuhiro Asahina

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Takashi Fujita

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Mamoru Watanabe

Antiviral actions of interferons

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language of work or name

English

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publication date

January 2013

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published in

Hepatology

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volume

57

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issue

1

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page(s)

46-58

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cites work

1 reference

The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors

21 January 2018

1 reference

New therapeutic approaches to hepatitis C virus

21 January 2018

1 reference

DNA microarray analysis of chimpanzee liver during acute resolving hepatitis C virus infection

21 January 2018

1 reference

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

1 reference

5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

1 reference

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

21 January 2018

1 reference

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

1 reference

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

21 January 2018

1 reference

VISA is an adapter protein required for virus-triggered IFN-beta signaling

21 January 2018

1 reference

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

21 January 2018

1 reference

Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300.

21 January 2018

1 reference

Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain

21 January 2018

1 reference

IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.

21 January 2018

1 reference

Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91

21 January 2018

1 reference

Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection

21 January 2018

1 reference

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

21 January 2018

1 reference

MAVS dimer is a crucial signaling component of innate immunity and the target of hepatitis C virus NS3/4A protease

21 January 2018

1 reference

Hepatitis C virus non-structural proteins responsible for suppression of the RIG-I/Cardif-induced interferon response

21 January 2018

1 reference

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

1 reference

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

21 January 2018

1 reference

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

1 reference

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

21 January 2018

1 reference

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

1 reference

Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

21 January 2018

1 reference

Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKepsilon molecular complex from the mitochondrial outer membrane by hepatitis C virus NS3-4A proteolytic cleavage

21 January 2018

1 reference

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs

21 January 2018

1 reference

Synergistic inhibition of intracellular hepatitis C virus replication by combination of ribavirin and interferon- alpha

21 January 2018

1 reference

Production of infectious hepatitis C virus in tissue culture from a cloned viral genome

21 January 2018

1 reference

Complete replication of hepatitis C virus in cell culture

21 January 2018

1 reference

Specific inhibition of hepatitis C virus replication by cyclosporin A.

21 January 2018

1 reference

Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3.

21 January 2018

1 reference

Mutations of the Hepatitis C virus protein NS4B on either side of the ER membrane affect the efficiency of subgenomic replicons

21 January 2018

1 reference

MAM: more than just a housekeeper

21 January 2018

1 reference

Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane

21 January 2018

1 reference

PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis

21 January 2018

1 reference

Design and implementation of bimolecular fluorescence complementation (BiFC) assays for the visualization of protein interactions in living cells

21 January 2018

1 reference

Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells

21 January 2018

1 reference

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

1 reference

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

1 reference

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

21 January 2018

1 reference

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

21 January 2018

1 reference

Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0.

21 January 2018

1 reference

Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex

21 January 2018

1 reference

Mobility of the hepatitis C virus NS4B protein on the endoplasmic reticulum membrane and membrane-associated foci

21 January 2018

1 reference

A nucleotide binding motif in hepatitis C virus (HCV) NS4B mediates HCV RNA replication

21 January 2018

1 reference

An N-terminal amphipathic helix in hepatitis C virus (HCV) NS4B mediates membrane association, correct localization of replication complex proteins, and HCV RNA replication

21 January 2018

1 reference

Interferon-beta is activated by hepatitis C virus NS5B and inhibited by NS4A, NS4B, and NS5A.

21 January 2018

1 reference

Identification of the nonstructural protein 4B of hepatitis C virus as a factor that inhibits the antiviral activity of interferon-alpha

21 January 2018

1 reference

Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis

21 January 2018

1 reference

New opportunities in anti-hepatitis C virus drug discovery: targeting NS4B.

21 January 2018

1 reference

Identification of a class of HCV inhibitors directed against the nonstructural protein NS4B.

21 January 2018

1 reference

A small molecule inhibits HCV replication and alters NS4B's subcellular distribution.

21 January 2018

1 reference

A new standard of care for the treatment of chronic HCV infection

21 January 2018

1 reference