MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases (Q24297671)

6

0 references

Elton Zeqiraj

9

0 references

Youcef Mehellou

Youcef Mehellou

3

0 references

Beatrice M. Filippi

Beatrice M Filippi

1

0 references

Dario Alessi

Dario R Alessi

10

0 references

Iva Navratilova

4

Iva Navratilova

0 references

Lorna Plater

7

Lorna Plater

0 references

author name string

Paola de los Heros

2

0 references

Robert Gourlay

5

0 references

Rachel Toth

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

8

0 references

language of work or name

English

0 references

publication date

4 May 2011

0 references

published in

The EMBO Journal

0 references

volume

30

0 references

issue

9

0 references

page(s)

1730-41

0 references

cites work

1 reference

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MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells

19 March 2017

1 reference

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Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

19 March 2017

1 reference

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An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

19 March 2017

1 reference

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Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

19 March 2017

1 reference

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MUSCLE: a multiple sequence alignment method with reduced time and space complexity

19 March 2017

1 reference

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LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

The protein kinase complement of the human genome

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

19 March 2017

1 reference

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Structural Comparison of Human Mammalian Ste20-Like Kinases

19 March 2017

1 reference

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Structures of human MST3 kinase in complex with adenine, ADP and Mn2+

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Crystal structure of domain-swapped STE20 OSR1 kinase domain

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Structure of the OSR1 kinase, a hypertension drug target

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Purification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Analysis of the LKB1-STRAD-MO25 complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Molecular cloning of a novel mRNA sequence expressed in cleavage stage mouse embryos

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

ALINE: a WYSIWYG protein-sequence alignment editor for publication-quality alignments

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

The Ste20 group kinases as regulators of MAP kinase cascades

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Fission yeast germinal center (GC) kinase Ppk11 interacts with Pmo25 and plays an auxiliary role in concert with the morphogenesis Orb6 network (MOR) in cell morphogenesis.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

SPAK-knockout mice manifest Gitelman syndrome and impaired vasoconstriction

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Role of the WNK-activated SPAK kinase in regulating blood pressure

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

SNF1/AMPK pathways in yeast

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Emerging roles of pseudokinases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

LKB1-dependent signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Fission yeast MO25 protein is localized at SPB and septum and is essential for cell morphogenesis.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

A regulatory locus of phosphorylation in the N terminus of the Na-K-Cl cotransporter, NKCC1.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Molecular characterization of the Drosophila Mo25 gene, which is conserved among Drosophila, mouse, and yeast

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101989

Regulatory phosphorylation sites in the NH2 terminus of the renal Na-K-Cl cotransporter (NKCC2).

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.78

Molecular characterization of HymA, an evolutionarily highly conserved and highly expressed protein of Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.78

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.78

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21423148

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2011.78

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMBOJ.2011.78

1 reference

1 reference

1 reference

PubMed publication ID

21423148

1 reference