A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R (Q24297906)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0072536

Interleukin 12 receptor subunit beta 1

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Interleukin 23 subunit alpha

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Interleukin 12B

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Interleukin 23 receptor

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positive regulation of tyrosine phosphorylation of STAT protein

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Interleukin 23 receptor

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Janus kinase 2

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author name string

Christi Parham

1

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Madaline Chirica

2

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Jacqueline Timans

3

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Elena Vaisberg

4

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Marilyn Travis

5

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Jeanne Cheung

6

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Stefan Pflanz

7

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Rebecca Zhang

8

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Komal P Singh

9

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Felix Vega

10

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Wayne To

11

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Janet Wagner

12

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Anne-Marie O'Farrell

13

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Terrill McClanahan

14

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Sandra Zurawski

15

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Charles Hannum

16

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Daniel Gorman

17

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Donna M Rennick

18

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Robert A Kastelein

19

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Rene de Waal Malefyt

20

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Kevin W Moore

Biological function and distribution of human interleukin-12 receptor beta chain

21

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language of work or name

English

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publication date

1 June 2002

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published in

Journal of Immunology

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volume

168

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issue

11

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page(s)

5699-708

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cites work

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Regulation of interleukin-12 receptor beta1 chain expression and interleukin-12 binding by human peripheral blood mononuclear cells

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Direct interaction of STAT4 with the IL-12 receptor

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Gene expression during differentiation of human dendritic cells from cord blood cd34 stem cells

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

A simple, non-chromatographic procedure to purify immunoglobulins from serum and ascites fluid

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

New experimental approaches in retrovirus-mediated expression screening

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NFkappaB.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

A bioactive designer cytokine for human hematopoietic progenitor cell expansion

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Structural design and molecular evolution of a cytokine receptor superfamily

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

A receptor for interleukin 10 is related to interferon receptors

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https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Efficient screening of retroviral cDNA expression libraries

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Formation of STAT5-containing DNA binding complexes in response to colony-stimulating factor-1 and platelet-derived growth factor

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Identification of a STAT4 binding site in the interleukin-12 receptor required for signaling

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

IL-12 responsiveness and expression of IL-12 receptor in human peripheral blood monocyte-derived dendritic cells

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Impaired IFN-gamma production in IFN regulatory factor-1 knockout mice during endotoxemia is secondary to a loss of both IL-12 and IL-12 receptor expression

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

The production of IFN-gamma by IL-12/IL-18-activated macrophages requires STAT4 signaling and is inhibited by IL-4.

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021

Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma

1 reference

https://api.crossref.org/works/10.4049%2FJIMMUNOL.168.11.5699

7 January 2021