Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds (Q24298231)

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26 January 2020

title

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds (English)

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26 January 2020

1 reference

GOA release 2020-03-11

identical protein binding

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GOA release 2020-03-11

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3

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26 January 2020

Armin Giese

5

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26 January 2020

author name string

Mario Caruana

1

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26 January 2020

Tobias Högen

2

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26 January 2020

Andreas Hillmer

4

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26 January 2020

Neville Vassallo

6

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26 January 2020

language of work or name

English

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publication date

31 March 2011

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26 January 2020

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26 January 2020

volume

585

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26 January 2020

issue

8

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26 January 2020

page(s)

1113-1120

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The aggregation and fibrillation of alpha-synuclein

26 January 2020

cites work

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Comparison of kindreds with parkinsonism and alpha-synuclein genomic multiplications

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Accelerated alpha-synuclein fibrillation in crowded milieu

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Fibrils formed in vitro from alpha-synuclein and two mutant forms linked to Parkinson's disease are typical amyloid

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Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

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Neurodegeneration with brain iron accumulation, type 1 is characterized by alpha-, beta-, and gamma-synuclein neuropathology

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The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease

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Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders

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The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

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EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

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EGCG remodels mature alpha-synuclein and amyloid-beta fibrils and reduces cellular toxicity.

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Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules

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Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

21 January 2018

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Small molecule inhibitors of alpha-synuclein filament assembly

21 January 2018

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Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein

21 January 2018

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Molecular mechanisms underlying the flavonoid-induced inhibition of alpha-synuclein fibrillation

21 January 2018

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Different species of alpha-synuclein oligomers induce calcium influx and seeding.

21 January 2018

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Single particle characterization of iron-induced pore-forming alpha-synuclein oligomers

21 January 2018

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Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron

21 January 2018

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Analysis of flavonoids and other phenolic compounds using high-performance liquid chromatography with coulometric array detection: relationship to antioxidant activity

21 January 2018

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Structure-antioxidant activity relationships of flavonoids and phenolic acids

21 January 2018

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Inhibition of amyloid fibril formation by polyphenols: structural similarity and aromatic interactions as a common inhibition mechanism

21 January 2018

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Natural polyphenols as inhibitors of amyloid aggregation. Molecular dynamics study of GNNQQNY heptapeptide decamer.

21 January 2018

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At low concentrations, 3,4-dihydroxyphenylacetic acid (DOPAC) binds non-covalently to alpha-synuclein and prevents its fibrillation

21 January 2018

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Flavonoid permeability across an in situ model of the blood-brain barrier

21 January 2018

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21 January 2018

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Differential effects of black versus green tea on risk of Parkinson's disease in the Singapore Chinese Health Study

21 January 2018

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Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway

21 January 2018

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Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

21 January 2018

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21 January 2018

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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

21 January 2018

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Single particle detection and characterization of synuclein co-aggregation

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.03.046

inferred from DOI database lookup

7 January 2021

based on heuristic

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2011.03.046

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.FEBSLET.2011.03.046

2 references

Consolidated OpenCitations Corpus – April 2017

496264

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21443877%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

496264

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

496264