Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol (Q24298758)

6

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Albert Neutzner

7

0 references

Richard J. Youle

9

object named as

Richard J Youle

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author name string

Frank Edlich

1

0 references

Soojay Banerjee

2

0 references

Motoshi Suzuki

3

0 references

Damien Arnoult

5

0 references

Nico Tjandra

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

8

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language of work or name

English

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publication date

1 April 2011

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published in

Cell

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volume

145

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page(s)

104-16

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issue

1

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cites work

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

19 March 2017

1 reference

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A stapled BID BH3 helix directly binds and activates BAX

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Efficient folding of proteins with multiple disulfide bonds in the Escherichia coli cytoplasm

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Conformation of the Bax C-terminus regulates subcellular location and cell death

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Movement of Bax from the cytosol to mitochondria during apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

19 March 2017

1 reference

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

19 March 2017

1 reference

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

19 March 2017

1 reference

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The BCL-2 protein family: opposing activities that mediate cell death

19 March 2017

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

7 April 2017

1 reference

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

1 reference

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The Bcl2 family: regulators of the cellular life-or-death switch

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

27 September 2017

1 reference

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A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Bcl-2 changes conformation to inhibit Bax oligomerization

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

An unconventional role for cytoplasmic disulfide bonds in vaccinia virus proteins

27 September 2017

1 reference

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Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Monitoring disulfide bond formation in the eukaryotic cytosol

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Formation of disulfide bridges by a single-chain Fv antibody in the reducing ectopic environment of the plant cytosol

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3070914

Apoptosis-resistant mitochondria in T cells selected for resistance to Fas signaling

29 November 2018

1 reference

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Nonionic detergents induce dimerization among members of the Bcl-2 family

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21458670

12 December 2020

inferred from PubMed ID database lookup

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21458670

12 December 2020

inferred from PubMed ID database lookup

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.034

7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.034

7 January 2021

Methodological advances in protein NMR

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.034

7 January 2021

Backbone dynamics of calmodulin studied by 15N relaxation using inverse detected two-dimensional NMR spectroscopy: the central helix is flexible.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.034

7 January 2021

Engineered disulfide bonds in recombinant human interferon-gamma: the impact of the N-terminal helix A and the AB-loop on protein stability

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2011.02.034

7 January 2021

10.1016/J.CELL.2011.02.034

Identifiers

DOI

1 reference

Fatcat

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30 July 2022

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Fatcat ID

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Fatcat

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30 July 2022

OpenCitations bibliographic resource ID

3558109

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

https://api.fatcat.wiki/v0/release/dagkzbh4evapjgzhi3ixopfxna

30 July 2022

https://api.fatcat.wiki/v0/release/dagkzbh4evapjgzhi3ixopfxna

1 reference

30 July 2022