BRCA1 affects global DNA methylation through regulation of DNMT1 (Q24298913)

positive regulation of histone H4-K16 acetylation

GOA release 2020-03-11

1 reference

Breast cancer 1, early onset

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Vivek Shukla

1

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Xavier Coumoul

2

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Tyler Lahusen

3

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Rui-Hong Wang

4

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Xiaoling Xu

5

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Athanassios Vassilopoulos

6

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Cuiying Xiao

7

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Mi-Hye Lee

8

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Yan-Gao Man

9

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Mutsuko Ouchi

10

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Toru Ouchi

11

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Chu-Xia Deng

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

12

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language of work or name

English

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publication date

November 2010

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published in

Cell Research

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volume

20

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issue

11

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page(s)

1201-15

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cites work

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Fgfr2 is required for limb outgrowth and lung-branching morphogenesis

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BRCA1: cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution

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A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

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Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure

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BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

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Chromosome territories, nuclear architecture and gene regulation in mammalian cells

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Somatic mutations in the neurofibromatosis 1 gene in human tumors

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Induction of Tumors in Mice by Genomic Hypomethylation

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Linking DNA methylation and histone modification: patterns and paradigms

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Chromatin modification and epigenetic reprogramming in mammalian development

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Gene silencing in cancer in association with promoter hypermethylation

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DNA methylation: past, present and future directions

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DNA methylation in breast and colorectal cancers

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Chromatin-remodelling mechanisms in cancer.

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DNA hypomethylation is prevalent even in low-grade breast cancers

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The Son of sevenless Gene Product: a Putative Activator of Ras

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DNA methyltransferases control telomere length and telomere recombination in mammalian cells

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Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis

21 January 2018

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Lessons learned from BRCA1 and BRCA2.

21 January 2018

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ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency

21 January 2018

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Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice

21 January 2018

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Tumor formation in Brca1 conditional mutant mice

21 January 2018

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Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

21 January 2018

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The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

21 January 2018

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A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

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Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis.

21 January 2018

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Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform

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A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation

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Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer.

21 January 2018

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CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis

21 January 2018

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Progressive alterations in global and GC-rich DNA methylation during tumorigenesis

21 January 2018

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Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

Crosstalk among Histone Modifications

21 January 2018

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A mechanistic view of genomic imprinting

21 January 2018

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The amino-terminus of mouse DNA methyltransferase 1 forms an independent domain and binds to DNA with the sequence involving PCNA binding motif.

21 January 2018

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Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1.

21 January 2018

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Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins

21 January 2018

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Transcriptional regulation of the base excision repair pathway by BRCA1

21 January 2018

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Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

21 January 2018

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Roles of BRCA1 in DNA damage repair: a link between development and cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

DNA methylation, chromatin inheritance, and cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

Aging, cancer and nutrition: the DNA methylation connection

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

BRCA1, hormone, and tissue-specific tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

A PP1-binding motif present in BRCA1 plays a role in its DNA repair function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

Global DNA hypomethylation in breast carcinoma: correlation with prognostic factors and tumor progression

21 January 2018

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https://api.crossref.org/works/10.1038%2FCR.2010.128

7 January 2021

Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

7 January 2021

Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

7 January 2021

Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

7 January 2021

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

7 January 2021

Global DNA hypomethylation in breast carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FCR.2010.128

7 January 2021