Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence (Q24299063)

GOA release 2020-03-11

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Porkodi Panneerselvam

1

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Laishram Pradeepkumar Singh

2

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Bow Ho

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Jianzhu Chen

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Jeak Ling Ding

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

5

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language of work or name

English

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publication date

1 March 2012

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published in

Biochemical Journal

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volume

442

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issue

2

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page(s)

263-71

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cites work

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A novel human gene (SARM) at chromosome 17q11 encodes a protein with a SAM motif and structural similarity to Armadillo/beta-catenin that is conserved in mouse, Drosophila, and Caenorhabditis elegans

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Amphioxus SARM involved in neural development may function as a suppressor of TLR signaling.

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TIR domain-containing adaptor SARM is a late addition to the ongoing microbe-host dialog

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Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response

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The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

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Regulation of anoxic death in Caenorhabditis elegans by mammalian apoptosis signal-regulating kinase (ASK) family proteins

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Mitochondria and apoptosis

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Single molecule resolution of the antimicrobial action of quantum dot-labeled sushi peptide on live bacteria

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Protein translocation into mitochondria: the role of TIM complexes

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Targeting of pre-ornithine transcarbamylase to mitochondria: definition of critical regions and residues in the leader peptide

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Mitochondria-targeted antioxidant peptides.

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Targeting antioxidants to mitochondria: a new therapeutic direction

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Mitochondria as a pharmacological target

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Mitochondria: new drug targets for oxidative stress-induced diseases

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Anti-cancer activity of targeted pro-apoptotic peptides

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Mitochondrial targeting sequences may form amphiphilic helices

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7 January 2021

Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK/T cell lymphoma revealed by gene expression profiling

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Mitochondrial leader sequences: structural similarities and sequence differences

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