The H50Q mutation enhances α-synuclein aggregation, secretion, and toxicity (Q24299289)

GOA release 2020-03-11

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1

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8 June 2020

Abid Oueslati

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8 June 2020

Francesco Simone Ruggeri

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Seung-Jae Lee

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8 June 2020

author name string

Igor Dikiy

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8 June 2020

Anne-Laure Mahul-Mellier

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8 June 2020

Martial K Mbefo

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8 June 2020

Filip Vercruysse

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Giovanni Dietler

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8 June 2020

David Eliezer

11

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8 June 2020

Bruno Fauvet

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Hilal A Lashuel

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8 June 2020

language of work or name

English

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publication date

8 August 2014

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number of pages

21

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Journal of Biological Chemistry

inferred from page(s)

published in

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8 June 2020

volume

289

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8 June 2020

issue

32

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8 June 2020

page(s)

21856-21876

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describes a project that uses

8 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4139205/fullTextXML

inferred from PubMed Central ID database lookup

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

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The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells.

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In vitro study of α-synuclein protofibrils by cryo-EM suggests a Cu(2+)-dependent aggregation pathway

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α-Synuclein mutations cluster around a putative protein loop

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

27 September 2017

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A novel α-synuclein missense mutation in Parkinson disease

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27 September 2017

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27 September 2017

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Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein

30 May 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

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Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure

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Conformational properties of alpha-synuclein in its free and lipid-associated states

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A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins

21 January 2018

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Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

21 January 2018

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Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein

21 January 2018

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Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

21 January 2018

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Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome

21 January 2018

1 reference

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The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro

21 January 2018

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NMR mapping of copper binding sites in alpha-synuclein

21 January 2018

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Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis

21 January 2018

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Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

21 January 2018

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A novel mechanism of interaction between alpha-synuclein and biological membranes

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24936070

12 December 2020

inferred from PubMed ID database lookup

Copper(II) binding by fragments of alpha-synuclein containing M1-D2- and -H50-residues; a combined potentiometric and spectroscopic study

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24936070

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M114.553297

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936070%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24936070%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

24936070

2 references