MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks (Q24299852)

6

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author name string

Manuel Stucki

1

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Julie A Clapperton

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Duaa Mohammad

3

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Michael B Yaffe

Rapid measurement of binding constants and heats of binding using a new titration calorimeter

4

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language of work or name

English

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publication date

29 December 2005

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published in

Cell

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volume

123

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issue

7

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page(s)

1213-26

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cites work

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H2AX: the histone guardian of the genome

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Control of sister chromatid recombination by histone H2AX.

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Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains

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Interactions between BRCT repeats and phosphoproteins: tangled up in two

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Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries

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Processing of X-ray diffraction data collected in oscillation mode

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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

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Histone H2A variants H2AX and H2AZ

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

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AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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MDC1 is a mediator of the mammalian DNA damage checkpoint

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MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

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Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

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Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

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Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

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Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

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Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.

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Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage

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Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX

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Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

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MDC1 regulates DNA-PK autophosphorylation in response to DNA damage

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NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response

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7 January 2021

Human PTIP facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation

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Megabase chromatin domains involved in DNA double-strand breaks in vivo

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7 January 2021

p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

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7 January 2021

Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

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Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

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7 January 2021

Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure

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Improved methods for building protein models in electron density maps and the location of errors in these models

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Phase combination and cross validation in iterated density-modification calculations

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Refinement of macromolecular structures by the maximum-likelihood method

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7 January 2021

Automated MAD and MIR structure solution

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7 January 2021

Genomic instability in mice lacking histone H2AX

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7 January 2021

The BRCT Domain Is a Phospho-Protein Binding Domain

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7 January 2021

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

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7 January 2021

ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

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7 January 2021

ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

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7 January 2021

Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage.

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