Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages (Q24299933)

negative regulation of cholesterol efflux

GOA release 2020-03-11

1 reference

Phospholipase A2, group X

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Preetha Shridas

1

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William M Bailey

2

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Florence Gizard

3

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Rob C Oslund

4

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Michael H Gelb

5

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Dennis Bruemmer

6

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Nancy R Webb

Arteriosclerosis, Thrombosis, and Vascular Biology

7

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language of work or name

English

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publication date

October 2010

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published in

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volume

30

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issue

10

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page(s)

2014-21

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cites work

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Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology

19 March 2017

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Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma

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Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor

19 March 2017

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Mutational analysis of human hydroxysteroid sulfotransferase SULT2B1 isoforms reveals that exon 1B of the SULT2B1 gene produces cholesterol sulfotransferase, whereas exon 1A yields pregnenolone sulfotransferase

19 March 2017

1 reference

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Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2

19 March 2017

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LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export

19 March 2017

1 reference

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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols

19 March 2017

1 reference

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Group X secretory phospholipase A2 negatively regulates adipogenesis in murine models

19 March 2017

1 reference

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Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands

27 September 2017

1 reference

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Phospholipase A2-modified low-density lipoprotein activates macrophage peroxisome proliferator-activated receptors

27 September 2017

1 reference

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Integration of metabolism and inflammation by lipid-activated nuclear receptors

27 September 2017

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27 September 2017

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Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model

27 September 2017

1 reference

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Liver X receptors regulate adrenal cholesterol balance

27 September 2017

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Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha

27 September 2017

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Promoter-specific roles for liver X receptor/corepressor complexes in the regulation of ABCA1 and SREBP1 gene expression

27 September 2017

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Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase

27 September 2017

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85-kDa cytosolic phospholipase A2 mediates peroxisome proliferator-activated receptor gamma activation in human lung epithelial cells.

27 September 2017

1 reference

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Potent modification of low density lipoprotein by group X secretory phospholipase A2 is linked to macrophage foam cell formation.

27 September 2017

1 reference

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Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

27 September 2017

1 reference

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Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Mouse group X secretory phospholipase A2 induces a potent release of arachidonic acid from spleen cells and acts as a ligand for the phospholipase A2 receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Recombinant production and properties of binding of the full set of mouse secreted phospholipases A2 to the mouse M-type receptor.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Reduction in myocardial ischemia/reperfusion injury in group X secretory phospholipase A2-deficient mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Transgenic expression of group V, but not group X, secreted phospholipase A2 in mice leads to neonatal lethality because of lung dysfunction.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of L

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Liver X receptors interact with corepressors to regulate gene expression

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2958102

Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20844270

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20844270

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Secreted phospholipase A2 inhibitors are also potent blockers of binding to the M-type receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20844270