The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase (Q24299948)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

title

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

oxidative RNA demethylase activity

10 January 2020

main subject

obesity

0 references

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0035515

oxidative DNA demethylase activity

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0035516

FTO alpha-ketoglutarate dependent dioxygenase

1 reference

Fat mass and obesity associated

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Inês Barroso

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Christopher J. Schofield

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Chris Ponting

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Patrik Rorsman

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Christophe Girard

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Giles See How Yeo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Michael A McDonough

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Anthony P Coll

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Sadaf Farooqi

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Stephen O'Rahilly

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

21

Tomas Lindahl

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

17

Zorica Jovanovic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

19

Barbara Sedgwick

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

23

Frances M Ashcroft

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

author name string

Thomas Gerken

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Yi-Chun Loraine Tung

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Celia J Webby

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Vladimir Saudek

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Kirsty S Hewitson

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Sharon Cunliffe

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Luke A McNeill

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Juris Galvanovskis

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Peter Robins

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Xavier Prieur

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

Marcella Ma

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

language of work or name

English

0 references

publication date

8 November 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

volume

318

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

issue

5855

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

page(s)

1469-1472

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

10 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Repair deficient mice reveal mABH2 as the primary oxidative demethylase for repairing 1meA and 3meC lesions in DNA

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Structure of a cephalosporin synthase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Variation in FTO contributes to childhood obesity and severe adult obesity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Repair of methylation damage in DNA and RNA by mammalian AlkB homologues

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Role of leptin in the neuroendocrine response to fasting

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Monogenic obesity in humans

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Reversal of DNA alkylation damage by two human dioxygenases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2668859

The mouse Fused toes (Ft) mutation is the result of a 1.6-Mb deletion including the entire Iroquois B gene cluster

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17991826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1151710

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

ADS bibcode

2007Sci...318.1469G

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17991826%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

2 references