Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma (Q24300058)

medulloblastoma

1 reference

Neuralized E3 ubiquitin protein ligase 1

1 reference

negative regulation of Notch signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

cerebellum cancer

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negative regulation of biological process

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notch receptors

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ubiquitin-protein ligases

1 reference

3

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author name string

Natalia Teider

1

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Deborah K Scott

2

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S Dilhan Weeraratne

4

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Vladimir M Amani

5

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Yifei Wang

6

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Victor E Marquez

7

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Yoon-Jae Cho

8

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Scott L Pomeroy

full work available at URL

9

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language of work or name

English

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publication date

December 2010

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018940/

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published in

Neuro-Oncology

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volume

12

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issue

12

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page(s)

1244-56

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copyright status

copyrighted

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cites work

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Mind bomb 1 is essential for generating functional Notch ligands to activate Notch

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19 March 2017

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Musashi1 modulates cell proliferation genes in the medulloblastoma cell line Daoy

7 April 2017

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Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

27 September 2017

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Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1.

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Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

27 September 2017

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27 September 2017

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

27 September 2017

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27 September 2017

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27 September 2017

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Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma

27 September 2017

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27 September 2017

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The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

27 September 2017

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27 September 2017

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The role of Notch in tumorigenesis: oncogene or tumour suppressor?

27 September 2017

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The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation

27 September 2017

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The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling

27 September 2017

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Establishment and characterization of four human medulloblastoma-derived cell lines

30 May 2018

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Differentiation characteristics of newly established medulloblastoma cell lines (D384 Med, D425 Med, and D458 Med) and their transplantable xenografts

30 May 2018

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Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice

30 May 2018

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Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation

21 January 2018

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Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias.

21 January 2018

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Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma

21 January 2018

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Neuralized functions as an E3 ubiquitin ligase during Drosophila development

21 January 2018

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Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

21 January 2018

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Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia

21 January 2018

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Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine

21 January 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3018940

Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development

29 November 2018

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29 November 2018

Identifiers

DOI

10.1093/NEUONC/NOQ091

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PMC publication ID

3018940

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