Osteocyte control of bone formation via sclerostin, a novel BMP antagonist (Q24300347)

negative regulation of BMP signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Sclerostin

1 reference

GOA release 2020-03-11

author name string

David G Winkler

1

0 references

May Kung Sutherland

2

0 references

James C Geoghegan

3

0 references

Changpu Yu

4

0 references

Trenton Hayes

5

0 references

John E Skonier

6

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Diana Shpektor

7

0 references

Mechtild Jonas

8

0 references

Brian R Kovacevich

9

0 references

Karen Staehling-Hampton

10

0 references

Mark Appleby

11

0 references

Mary E Brunkow

12

0 references

John A Latham

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

13

0 references

language of work or name

English

0 references

publication date

1 December 2003

0 references

published in

The EMBO Journal

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volume

22

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issue

23

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page(s)

6267-76

0 references

cites work

1 reference

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

19 March 2017

1 reference

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

19 March 2017

1 reference

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Crystal structure of the BMP-2-BRIA ectodomain complex

19 March 2017

1 reference

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Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

19 March 2017

1 reference

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The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex

19 March 2017

1 reference

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Multilineage potential of adult human mesenchymal stem cells

19 March 2017

1 reference

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Osteopetrosis with syndactyly; a morphological variant of Albers-Schönberg's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Lack of association between the SOST gene and bone mineral density in perimenopausal women: analysis of five polymorphisms

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

19 March 2017

1 reference

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Bone morphogenetic protein-2 causes commitment and differentiation in C3H10T1/2 and 3T3 cells

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Differentiation of murine preosteoblastic KS483 cells depends on autocrine bone morphogenetic protein signaling during all phases of osteoblast formation

27 September 2017

1 reference

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Do bone cells behave like a neuronal network?

27 September 2017

1 reference

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Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.

27 September 2017

1 reference

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Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Molecular events caused by mechanical stress in bone

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

The mouse osteocalcin gene cluster contains three genes with two separate spatial and temporal patterns of expression.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Developmental regulation of myosin gene expression in mouse cardiac muscle

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

The clinical features of sclerosteosis. A review of the manifestations in twenty-five affected individuals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Human bone marrow osteoprogenitors express estrogen receptor-alpha and bone morphogenetic proteins 2 and 4 mRNA during osteoblastic differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

A role for the BMP antagonist chordin in endochondral ossification.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Overexpression of DAN causes a growth suppression in p53-deficient SAOS-2 cells.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Sclerosteosis: neurogenetic and pathophysiologic analysis of an American kinship.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=291840

Cranial CT findings in sclerosteosis

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/14633986

12 December 2020

inferred from PubMed ID database lookup

Ethanol stimulates expression of functional H+,K(+)-ATPase in SF9 cells

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Interaction of fluorescein isothiocyanate with the (H+ + K+)-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Direct evidence for an ADP-sensitive phosphointermediate of (K+ + H+)-ATPase.

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Eosin, a fluorescent marker for the high-affinity ATP site of (K+ + H+)-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Conformational states of (K+ + H+)-ATPase studied using tryptic digestion as a tool

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

A monoclonal antibody against pig gastric H+/K(+)-ATPase, which binds to the cytosolic E1.K+ form

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Phosphorylation of H+/K+-ATPase by inorganic phosphate. The role of K+ and SCH 28080

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Tertiary amines as antagonists of both the luminal and cytosolic K(+)-site of gastric H,K-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Functional expression of gastric H,K-ATPase using the baculovirus expression system

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Structural organization, ion transport, and energy transduction of P-type ATPases

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Identification of Asp804 and Asp808 as Na+ and K+ coordinating residues in alpha-subunit of renal Na,K-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Determination of total protein

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Mutant Glu781-->Ala of the rat kidney Na+,K(+)-ATPase displays low cation affinity and catalyzes ATP hydrolysis at a high rate in the absence of potassium ions.

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Occlusion of K ions in the unphosphorylated sodium pump

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA.

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Location of high affinity Ca2+-binding sites within the predicted transmembrane domain of the sarcoplasmic reticulum Ca2+-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

The negative charge of glutamic acid-820 in the gastric H+,K+-ATPase alpha-subunit is essential for K+ activation of the enzyme activity

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Sodium acts as a potassium analog on gastric H,K-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Two residues that may ligate Ca2+ in transmembrane domain six of the plasma membrane Ca(2+)-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Asp804 and Asp808 in the transmembrane domain of the Na,K-ATPase alpha subunit are cation coordinating residues

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Role of negatively charged residues in the fifth and sixth transmembrane domains of the catalytic subunit of gastric H+,K+-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

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1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Mutational analysis of putative SCH 28080 binding sites of the gastric H+,K+-ATPase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG599

7 January 2021

Functional consequences of mutations in the transmembrane core region for cation translocation and energy transduction in the Na+,K(+)-ATPase and the SR Ca(2+)-ATPase

1 reference

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7 January 2021

Identifiers

DOI

10.1093/EMBOJ/CDG599

1 reference

1271000

1271000

1 reference

1 reference

1 reference