Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation (Q24300395)

somatic hypermutation of immunoglobulin genes

1 reference

Nucleolin

1 reference

Activation-induced cytidine deaminase

1 reference

SPT6, histone chaperone and transcription elongation factor

1 reference

Tripartite motif-containing 28

1 reference

12

Tasuku Honjo

0 references

Il-Mi Okazaki

object named as

Il-mi Okazaki

1

0 references

Tohru Natsume

object named as

Tohru Natsume

10

0 references

author name string

Katsuya Okawa

2

0 references

Maki Kobayashi

3

0 references

Kiyotsugu Yoshikawa

4

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Shimpei Kawamoto

5

0 references

Hitoshi Nagaoka

6

0 references

Reiko Shinkura

7

0 references

Yoko Kitawaki

8

0 references

Hisaaki Taniguchi

9

0 references

Shun-Ichiro Iemura

Proceedings of the National Academy of Sciences of the United States of America

11

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language of work or name

English

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publication date

10 May 2011

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published in

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volume

108

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issue

19

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page(s)

7920-5

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cites work

Prdm9 controls activation of mammalian recombination hotspots

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The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation

19 March 2017

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Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1

19 March 2017

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The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export

19 March 2017

1 reference

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Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

19 March 2017

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RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

19 March 2017

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The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA

19 March 2017

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

19 March 2017

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Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination

19 March 2017

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Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5

27 September 2017

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Cutting edge: CTNNBL1 is dispensable for Ig class switch recombination

27 September 2017

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Discrete DNA sites regulate global distribution of meiotic recombination

27 September 2017

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Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination

27 September 2017

1 reference

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PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice

27 September 2017

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The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination

27 September 2017

1 reference

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Carboxy-terminal domain of AID required for its mRNA complex formation in vivo

27 September 2017

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A plant homeodomain in RAG-2 that binds Hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

27 September 2017

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Discovery of activation-induced cytidine deaminase, the engraver of antibody memory

27 September 2017

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Activation-induced cytidine deaminase: structure-function relationship as based on the study of mutants

27 September 2017

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PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells

27 September 2017

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The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

27 September 2017

1 reference

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MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells

27 September 2017

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The double-edged sword of activation-induced cytidine deaminase.

27 September 2017

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

27 September 2017

1 reference

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Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3093487

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

27 September 2017

1 reference

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Linking class-switch recombination with somatic hypermutation

27 September 2017

1 reference

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Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

27 September 2017

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Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation

27 September 2017

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The AID enzyme induces class switch recombination in fibroblasts

30 May 2018

1 reference

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Two levels of protection for the B cell genome during somatic hypermutation.

30 May 2018

1 reference

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Transcription-coupled events associating with immunoglobulin switch region chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104423108

Separate domains of AID are required for somatic hypermutation and class-switch recombination

21 January 2018

1 reference

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AID mutant analyses indicate requirement for class-switch-specific cofactors

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1104423108