LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status (Q24300605)

2

0 references

Steve M Riddle

3

0 references

Connie S Lebakken

4

0 references

R Jeremy Nichols

Frontiers in Molecular Neuroscience

5

0 references

language of work or name

English

0 references

publication date

2014

0 references

published in

1 reference

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

volume

7

0 references

page(s)

54

0 references

cites work

1 reference

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GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

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The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

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LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

19 March 2017

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation

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Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease

19 March 2017

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Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

7 April 2017

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

7 April 2017

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Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

7 April 2017

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Loss of leucine-rich repeat kinase 2 (LRRK2) in rats leads to progressive abnormal phenotypes in peripheral organs

7 April 2017

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Contribution of GTPase activity to LRRK2-associated Parkinson disease

27 September 2017

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Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants

27 September 2017

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Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors

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LRRK2 Parkinson disease mutations enhance its microtubule association.

27 September 2017

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Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

27 September 2017

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27 September 2017

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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

27 September 2017

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

27 September 2017

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Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

27 September 2017

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27 September 2017

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27 September 2017

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Parkinson's disease-related LRRK2 G2019S mutation results from independent mutational events in humans

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Lrrk2 and Lewy body disease

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21 January 2018

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Dopamine turnover increases in asymptomatic LRRK2 mutations carriers

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LRRK2 mutations in Parkinson disease

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21 January 2018

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21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25009464

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25009464

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3389/FNMOL.2014.00054

1 reference

1 reference

1 reference

PubMed publication ID

25009464

1 reference