Y14 and hUpf3b form an NMD-activating complex (Q24300691)

GOA release 2020-03-11

Matthias W Hentze

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Niels H Gehring

1

object named as

Niels H Gehring

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author name string

Gabriele Neu-Yilik

2

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Thomas Schell

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Andreas E Kulozik

Nonsense mutations inhibit RNA splicing in a cell-free system: recognition of mutant codon is independent of protein synthesis

5

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language of work or name

English

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publication date

April 2003

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published in

Molecular Cell

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volume

11

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page(s)

939-49

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issue

4

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cites work

1 reference

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7 January 2021

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Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

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Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

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7 January 2021

The human intronless melanocortin 4-receptor gene is NMD insensitive

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7 January 2021

A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro

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Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon

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RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer

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Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover

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Translation driven by an eIF4G core domain in vivo

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Tethered-function analysis reveals that elF4E can recruit ribosomes independent of its binding to the cap structure.

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7 January 2021

Translation is required to remove Y14 from mRNAs in the cytoplasm

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7 January 2021

Nonsense-mediated mRNA decay in health and disease

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Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia

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Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant

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7 January 2021

A perfect message: RNA surveillance and nonsense-mediated decay

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mRNA surveillance in eukaryotes: kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

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7 January 2021

Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm

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7 January 2021

Magoh, a human homolog of Drosophila mago nashi protein, is a component of the splicing-dependent exon-exon junction complex

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Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

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7 January 2021

The Y14 protein communicates to the cytoplasm the position of exon-exon junctions

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Nuclear degradation of nonsense mutated beta-globin mRNA: a post-transcriptional mechanism to protect heterozygotes from severe clinical manifestations of beta-thalassemia?

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The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

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7 January 2021

The protein Mago provides a link between splicing and mRNA localization.

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7 January 2021

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

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7 January 2021

NMR structure of the bacteriophage lambda N peptide/boxB RNA complex: recognition of a GNRA fold by an arginine-rich motif

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Nonsense surveillance in lymphocytes?

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7 January 2021

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

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7 January 2021

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1

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7 January 2021

Quality control of mRNA function

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7 January 2021

Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay

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7 January 2021

Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes

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7 January 2021

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

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A protein-RNA interaction network facilitates the template-independent cooperative assembly on RNA polymerase of a stable antitermination complex containing the lambda N protein

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7 January 2021

RNA events. No end to nonsense

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7 January 2021

Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.

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7 January 2021

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

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7 January 2021

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

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Mammalian orthologues of a yeast regulator of nonsense transcript stability

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5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

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7 January 2021

Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway

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Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

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Cytoplasmic mRNA for human triosephosphate isomerase is immune to nonsense-mediated decay despite forming polysomes

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7 January 2021

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells

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Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position

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7 January 2021

Binary specification of nonsense codons by splicing and cytoplasmic translation

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7 January 2021

A quality control pathway that down-regulates aberrant T-cell receptor (TCR) transcripts by a mechanism requiring UPF2 and translation

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7 January 2021

Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

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7 January 2021

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

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7 January 2021

10.1016/S1097-2765(03)00142-4

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1400781

1400781

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference