A global control region defines a chromosomal regulatory landscape containing the HoxD cluster (Q24301317)

GOA release 2020-03-11

limb development

1 reference

GOA release 2020-03-11

3

Denis Duboule

Denis

Duboule

1 reference

PubMed

PubMed publication ID

9 December 2023

1

François Spitz

François

Spitz

1 reference

PubMed

PubMed publication ID

9 December 2023

Federico Gonzalez

2

Federico

Gonzalez

1 reference

PubMed

PubMed publication ID

12732147

Basic local alignment search tool

9 December 2023

language of work or name

English

0 references

publication date

2 May 2003

0 references

published in

Cell

0 references

volume

113

0 references

issue

3

0 references

page(s)

405-17

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Absence of radius and ulna in mice lacking hoxa-11 andhoxd-11

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Numerous potentially functional but non-genic conserved sequences on human chromosome 21

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Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation.

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A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly

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Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns.

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Hox gene expression in limbs: colinearity by opposite regulatory controls.

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Function of the Evx-2 gene in the morphogenesis of vertebrate limbs

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Enhancer sharing in a plasmid model containing the alpha-fetoprotein and albumin promoters

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Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs.

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Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing.

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Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells.

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An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster.

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Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations

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