WRN interacts physically and functionally with the recombination mediator protein RAD52 (Q24301932)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

3

Magnar Bjørås

0 references

Marit Otterlei

2

object named as

Marit Otterlei

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author name string

Kathy Baynton

1

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Cayetano von Kobbe

4

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Vilhelm A Bohr

5

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Erling Seeberg

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

19 September 2003

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published in

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volume

278

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issue

38

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page(s)

36476-86

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

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Gatekeepers of recombination

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A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities

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Telomerase prevents the accelerated cell ageing of Werner syndrome fibroblasts

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inferred from DOI database lookup

7 January 2021

based on heuristic

SGS1 is required for telomere elongation in the absence of telomerase

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