Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly (Q24301969)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0032797

Gem nuclear organelle associated protein 8

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ribonucleoprotein complex

GOA release 2020-03-11

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7

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Claudia Carissimi

object named as

Claudia Carissimi

1

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Alan Sawyer

object named as

Alan Sawyer

6

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Livio Pellizzoni

object named as

Livio Pellizzoni

8

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author name string

Luciano Saieva

2

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Jennifer Baccon

3

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Pieranna Chiarella

4

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Alessio Maiolica

Journal of Biological Chemistry

5

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language of work or name

English

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publication date

24 March 2006

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published in

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volume

281

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issue

12

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page(s)

8126-34

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cites work

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Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs

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SMN-mediated assembly of RNPs: a complex story

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Why do cells need an assembly machine for RNA-protein complexes?

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Identification and characterization of a spinal muscular atrophy-determining gene

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The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins

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Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems

21 January 2018

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Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli

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Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins

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Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component

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Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex

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The SMN complex, an assemblyosome of ribonucleoproteins

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The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins

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A novel WD repeat protein component of the methylosome binds Sm proteins

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Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln

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Unrip is a component of SMN complexes active in snRNP assembly

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Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization

21 January 2018

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A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs

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Essential role for the SMN complex in the specificity of snRNP assembly

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Assisted RNP assembly: SMN and PRMT5 complexes cooperate in the formation of spliceosomal UsnRNPs

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The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway

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SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta

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Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein

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Biogenesis of small nuclear RNPs

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Sequence-specific interaction of U1 snRNA with the SMN complex

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snRNAs contain specific SMN-binding domains that are essential for snRNP assembly

21 January 2018

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Lymphotropic Herpesvirus saimiri uses the SMN complex to assemble Sm cores on its small RNAs

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Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing

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Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.

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Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

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The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure

21 January 2018

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The Schizosaccharomyces pombe protein Yab8p and a novel factor, Yip1p, share structural and functional similarity with the spinal muscular atrophy-associated proteins SMN and SIP1.

21 January 2018

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Charcot-Marie-Tooth neuropathies: from clinical description to molecular genetics

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Localization of non-specific X-linked mental retardation gene (MRX73) to Xp22.2.

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The centennial of the Cajal body.

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21 January 2018

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Coilin methylation regulates nuclear body formation

21 January 2018

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A cell system with targeted disruption of the SMN gene: functional conservation of the SMN protein and dependence of Gemin2 on SMN.

21 January 2018

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Co-regulation of survival of motor neuron (SMN) protein and its interactor SIP1 during development and in spinal muscular atrophy

21 January 2018

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Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1

21 January 2018

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SMN mutants of spinal muscular atrophy patients are defective in binding to snRNP proteins.

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The Relationship between SMN, the Spinal Muscular Atrophy Protein, and Nuclear Coiled Bodies in Differentiated Tissues and Cultured Cells

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A novel nuclear structure containing the survival of motor neurons protein

21 January 2018

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7 January 2021

High throughput production of mouse monoclonal antibodies using antigen microarrays

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SMN oligomerization defect correlates with spinal muscular atrophy severity

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7 January 2021

Gemins modulate the expression and activity of the SMN complex

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7 January 2021