Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro (Q24302444)

regulation of cargo loading into COPII-coated vesicle

GO:1901309

1 reference

positive regulation of sterol regulatory element binding protein cleavage

GO:1901301

1 reference

negative regulation of cargo loading into COPII-coated vesicle

GO:1901310

2 references

GO:1901303

GOA release 2020-03-11

Insulin induced gene 1

1 reference

SEC23 homolog A, COPII coat complex component

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

3

Joseph L Goldstein

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author name string

Li-Ping Sun

series ordinal

1

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Lu Li

series ordinal

2

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Michael S Brown

series ordinal

4

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language of work or name

English

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publication date

15 July 2005

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published in

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volume

280

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issue

28

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page(s)

26483-90

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cites work

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Bi-directional protein transport between the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Isolation of mutant cells lacking Insig-1 through selection with SR-12813, an agent that stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Structure and function in rhodopsin: a tetracycline-inducible system in stable mammalian cell lines for high-level expression of opsin mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Failure to cleave sterol regulatory element-binding proteins (SREBPs) causes cholesterol auxotrophy in Chinese hamster ovary cells with genetic absence of SREBP cleavage-activating protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Expression and purification of mammalian Sarl

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

COPII vesicles derived from mammalian endoplasmic reticulum microsomes recruit COPI

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Signals for COPII-dependent export from the ER: what's the ticket out?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

21 January 2018

Getting into the Golgi

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Cargo selection by the COPII budding machinery during export from the ER

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

COPII: a membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

Dynamics of the COPII coat with GTP and stable analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

The mechanisms of vesicle budding and fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

SNARE selectivity of the COPII coat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200

19 Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M504041200