The mechanism of nuclear export of Smad3 involves exportin 4 and Ran (Q24302636)

RAN, member RAS oncogene family

1 reference

Exportin 4

1 reference

Nuclear transport factor 2

1 reference

positive regulation of protein export from nucleus

1 reference

author name string

Akira Kurisaki

1

0 references

Keiko Kurisaki

2

0 references

Marcin Kowanetz

3

0 references

Hiromu Sugino

4

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Yoshihiro Yoneda

5

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Carl-Henrik Heldin

6

0 references

Aristidis Moustakas

Molecular and Cellular Biology

7

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language of work or name

English

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publication date

February 2006

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published in

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volume

26

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issue

4

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page(s)

1318-32

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cites work

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

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Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes

19 March 2017

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Structural basis of Smad2 recognition by the Smad anchor for receptor activation

19 March 2017

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Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

19 March 2017

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The role of exportin-t in selective nuclear export of mature tRNAs

19 March 2017

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Identification of a tRNA-specific nuclear export receptor

19 March 2017

1 reference

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Dominant-negative mutants of importin-beta block multiple pathways of import and export through the nuclear pore complex

19 March 2017

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Transport between the cell nucleus and the cytoplasm

19 March 2017

1 reference

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Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling

19 March 2017

1 reference

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The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

19 March 2017

1 reference

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A structural basis for mutational inactivation of the tumour suppressor Smad4

19 March 2017

1 reference

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CRM1 is an export receptor for leucine-rich nuclear export signals

19 March 2017

1 reference

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Nucleocytoplasmic transport: the soluble phase

19 March 2017

1 reference

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Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif

19 March 2017

1 reference

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Importin beta mediates nuclear translocation of Smad 3

19 March 2017

1 reference

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Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

19 March 2017

1 reference

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Specificity and versatility in tgf-beta signaling through Smads

19 March 2017

1 reference

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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

7 April 2017

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Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition

7 April 2017

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Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation

27 September 2017

1 reference

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Nucleocytoplasmic shuttling of signal transducers.

27 September 2017

1 reference

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Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif

27 September 2017

1 reference

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Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

In or out? The dynamics of Smad nucleocytoplasmic shuttling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

A distinct nuclear localization signal in the N terminus of Smad 3 determines its ligand-induced nuclear translocation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

A monoclonal antibody to the COOH-terminal acidic portion of Ran inhibits both the recycling of Ran and nuclear protein import in living cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

beta-subunit of nuclear pore-targeting complex (importin-beta) can be exported from the nucleus in a Ran-independent manner

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein import

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Exogenously injected nuclear import factor p10/NTF2 inhibits signal-mediated nuclear import and export of proteins in living cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Loss of RCC1 leads to suppression of nuclear protein import in living cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

A novel nuclear export signal in Smad1 is essential for its signaling activity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Analysis of Smad nucleocytoplasmic shuttling in living cells.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1367208

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16449645

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Nuclear protein import using digitonin-permeabilized cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16449645