IRAK-M is a negative regulator of Toll-like receptor signaling (Q24302640)

negative regulation of innate immune response

GOA release 2020-03-11

1 reference

Interleukin-1 receptor-associated kinase 3

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

5

Ruslan Medzhitov

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Richard Flavell

6

object named as

Richard A Flavell

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Charles Janeway

4

object named as

Charles A Janeway

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author name string

Koichi Kobayashi

1

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Lorraine D Hernandez

2

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Jorge E Galán

Toll-like receptors: critical proteins linking innate and acquired immunity

3

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language of work or name

English

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publication date

26 July 2002

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published in

Cell

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volume

110

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page(s)

191-202

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issue

2

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cites work

1 reference

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7 January 2021

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

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TOLERANCE TO BACTERIAL PYROGENS : I. FACTORS INFLUENCING ITS DEVELOPMENT.

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Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin

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7 January 2021

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

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7 January 2021

IRAK: a kinase associated with the interleukin-1 receptor

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7 January 2021

Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity

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Salmonella spp. are cytotoxic for cultured macrophages.

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The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli

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7 January 2021

Endotoxemia in human septic shock

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Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction

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7 January 2021

Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells

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7 January 2021

Hyporesponsiveness to lipopolysaccharide alters the composition of NF-kappaB binding to the regulatory regions of inducible nitric oxide synthase gene

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Mechanisms of endotoxin tolerance. IV. Specificity of the pyrogenic refractory state during continuous intravenous infusions of endotoxin

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The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

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A Toll-like receptor recognizes bacterial DNA

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7 January 2021

TIRAP: an adapter molecule in the Toll signaling pathway

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7 January 2021

Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production

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7 January 2021

The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins.

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7 January 2021

Unresponsiveness of MyD88-deficient mice to endotoxin

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7 January 2021

Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity

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7 January 2021

Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation

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7 January 2021

Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells

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7 January 2021

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase

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7 January 2021

IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase

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7 January 2021

Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-κB

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7 January 2021

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

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7 January 2021

Innate immunity: the virtues of a nonclonal system of recognition

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

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7 January 2021

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

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7 January 2021

Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells

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7 January 2021

Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression

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7 January 2021

Non-invasive Salmonella typhimurium mutants are avirulent because of an inability to enter and destroy M cells of ileal Peyer's patches

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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7 January 2021

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)

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7 January 2021

Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration

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7 January 2021

Toll-like receptors control activation of adaptive immune responses

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7 January 2021

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

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7 January 2021

IL-1 receptor-associated kinase modulates host responsiveness to endotoxin.

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

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7 January 2021

Crohn's disease: genetic susceptibility, bacteria, and innate immunity

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7 January 2021

MyD88: an adapter that recruits IRAK to the IL-1 receptor complex

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7 January 2021

IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family

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7 January 2021

The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation

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7 January 2021

Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.

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7 January 2021

10.1016/S0092-8674(02)00827-9

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1035365

1035365

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference