The R1441C mutation of LRRK2 disrupts GTP hydrolysis (Q24303406)

protein autophosphorylation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Elisa Greggio

2

0 references

Alexandra Beilina

3

0 references

Patrick A. Lewis

object named as

Patrick A Lewis

1

0 references

Mark R Cookson

6

object named as

Mark R Cookson

0 references

author name string

Shushant Jain

4

0 references

Acacia Baker

Biochemical and Biophysical Research Communications

5

0 references

language of work or name

English

0 references

publication date

8 June 2007

0 references

published in

0 references

volume

357

0 references

issue

3

0 references

page(s)

668-71

0 references

cites work

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Kinase activity of mutant LRRK2 mediates neuronal toxicity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

A common LRRK2 mutation in idiopathic Parkinson's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

LRRK1 protein kinase activity is stimulated upon binding of GTP to its Roc domain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Roc, a Ras/GTPase domain in complex proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1939973

Genetic screening for a single common LRRK2 mutation in familial Parkinson's disease

27 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17442267

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The Parkinson disease gene LRRK2: evolutionary and structural insights

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17442267

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.BBRC.2007.04.006

1 reference

1 reference

1 reference

PubMed publication ID

17442267

1 reference