Ubiquitination by TOPORS regulates the prostate tumor suppressor NKX3.1 (Q24303410)

proteasome-mediated ubiquitin-dependent protein catabolic process

GOA release 2020-03-11

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GOA release 2020-03-11

protein ubiquitination

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1 reference

1

Bin Guan

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author name string

Pooja Pungaliya

2

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Xiang Li

3

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Carlos Uquillas

4

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Laura N Mutton

5

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Eric H Rubin

6

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Charles J Bieberich

Journal of Biological Chemistry

7

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language of work or name

English

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publication date

22 February 2008

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published in

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volume

283

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page(s)

4834-40

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issue

8

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cites work

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NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells

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Recognition of the polyubiquitin proteolytic signal

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Ubiquitin and ubiquitin-like proteins as multifunctional signals

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NKX3.1 homeodomain protein binds to topoisomerase I and enhances its activity

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Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein

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Identification of a novel gene encoding a p53-associated protein

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Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

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The topoisomerase I- and p53-binding protein topors is differentially expressed in normal and malignant human tissues and may function as a tumor suppressor

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Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF.

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The topoisomerase I-binding RING protein, topors, is associated with promyelocytic leukemia nuclear bodies

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Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain

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Drosophila Topors is a RING finger-containing protein that functions as a ubiquitin-protein isopeptide ligase for the hairy basic helix-loop-helix repressor protein

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Nkx3.1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells

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Mapping protein post-translational modifications with mass spectrometry

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Preferred in vivo ubiquitination sites.

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High frequency of deletion on chromosome 9p21 may harbor several tumor-suppressor genes in human prostate cancer

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Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo

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TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins

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SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

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Haploinsufficiency at the Nkx3.1 locus. A paradigm for stochastic, dosage-sensitive gene regulation during tumor initiation

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NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.

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Tissue-specific expression of murine Nkx3.1 in the male urogenital system

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Physical and functional interactions between the prostate suppressor homeoprotein NKX3.1 and serum response factor

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inferred from DOI database lookup

7 January 2021

based on heuristic

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inferred from DOI database lookup

7 January 2021

based on heuristic

Proteasomes degrade proteins in focal subdomains of the human cell nucleus

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