Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus (Q24303519)

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12 January 2020

title

Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus (English)

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12 January 2020

1

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12 January 2020

Graeme M Birdsey

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12 January 2020

Daniel R Knight

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12 January 2020

author name string

Michael J Lumb

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12 January 2020

David T R Prowse

4

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12 January 2020

Tommy J Perkins

5

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12 January 2020

Christopher J Danpure

7

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language of work or name

English

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publication date

23 May 2005

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Journal of Biological Chemistry

12 January 2020

published in

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volume

280

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12 January 2020

issue

29

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12 January 2020

page(s)

27111-27120

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An enzyme trafficking defect in two patients with primary hyperoxaluria type 1: peroxisomal alanine/glyoxylate aminotransferase rerouted to mitochondria

12 January 2020

cites work

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Identification of mutations associated with peroxisome-to-mitochondrion mistargeting of alanine/glyoxylate aminotransferase in primary hyperoxaluria type 1

21 January 2018

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Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation

21 January 2018

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Inhibition of alanine:glyoxylate aminotransferase 1 dimerization is a prerequisite for its peroxisome-to-mitochondrion mistargeting in primary hyperoxaluria type 1.

21 January 2018

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Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeti

21 January 2018

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Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon

21 January 2018

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A conserved tripeptide sorts proteins to peroxisomes

21 January 2018

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Targeting efficiencies of various permutations of the consensus C-terminal tripeptide peroxisomal targeting signal

21 January 2018

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PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Saccharomyces cerevisiae

21 January 2018

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The tetratricopeptide repeat-domain of the PAS10 protein of Saccharomyces cerevisiae is essential for binding the peroxisomal targeting signal-SKL.

21 January 2018

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Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5

21 January 2018

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The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it.

21 January 2018

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Motif refinement of the peroxisomal targeting signal 1 and evaluation of taxon-specific differences

21 January 2018

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Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence

21 January 2018

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Correlating structure and affinity for PEX5:PTS1 complexes

21 January 2018

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Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the marmoset and rabbit genes

21 January 2018

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Evolution of alanine:glyoxylate aminotransferase intracellular targeting: structural and functional analysis of the guinea pig gene

21 January 2018

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Nucleotide sequence of the cDNA encoding the precursor for mitochondrial serine:pyruvate aminotransferase of rat liver

21 January 2018

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The mouse alanine:glyoxylate aminotransferase gene (Agxt1): cloning, expression, and mapping to chromosome 1.

21 January 2018

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Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the feline gene

21 January 2018

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Differential enzyme targeting as an evolutionary adaptation to herbivory in carnivora

21 January 2018

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Molecular basis for the dual mitochondrial and cytosolic localization of alanine:glyoxylate aminotransferase in amphibian liver cells

21 January 2018

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Molecular adaptation of alanine:glyoxylate aminotransferase targeting in primates

21 January 2018

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Analysis of the carboxyl-terminal peroxisomal targeting signal 1 in a homologous context in Saccharomyces cerevisiae

21 January 2018

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Pex5p binding affinities for canonical and noncanonical PTS1 peptides.

21 January 2018

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Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence

21 January 2018

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Crystal structure of alanine:glyoxylate aminotransferase and the relationship between genotype and enzymatic phenotype in primary hyperoxaluria type 1

21 January 2018

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An isoform of pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes

21 January 2018

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Diet and the frequency of the alanine:glyoxylate aminotransferase Pro11Leu polymorphism in different human populations

21 January 2018

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Alanine glyoxylate aminotransferase and the urinary excretion of oxalate and glycollate in hyperoxaluria type I and the Zellweger syndrome

21 January 2018

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Genetic heterogeneity in primary hyperoxaluria type 1: impact on diagnosis

21 January 2018

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The AGT gene in Africa: a distinctive minor allele haplotype, a polymorphism (V326I), and a novel PH1 mutation (A112D) in Black Africans

21 January 2018

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Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations

21 January 2018

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Cytosolic compartmentalization of hepatic alanine:glyoxylate aminotransferase in patients with aberrant peroxisomal biogenesis and its effect on oxalate metabolism

21 January 2018

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7 January 2021

Analyses in transfected cells and in vitro of a putative peroxisomal targeting signal of rat liver serine:pyruvate aminotransferase

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7 January 2021

Effect of N-terminal alpha-helix formation on the dimerization and intracellular targeting of alanine:glyoxylate aminotransferase

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7 January 2021

A comparative analysis of the evolutionary relationship between diet and enzyme targeting in bats, marsupials and other mammals

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7 January 2021

Context dependency of the PTS1 motif in human alanine: glyoxylate aminotransferase 1

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7 January 2021

Identifiers

DOI

10.1074/JBC.M502719200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15911627%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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