The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3 (Q24303524)

Major histocompatibility complex, class II, DR alpha

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Major histocompatibility complex, class II, DR beta 1

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protein folding chaperone activity

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author name string

P Ghosh

1

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M Amaya

2

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E Mellins

3

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D C Wiley

Assembly, transport, and function of MHC class II molecules

4

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language of work or name

English

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publication date

30 November 1995

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published in

Nature

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volume

378

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issue

6556

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page(s)

457-62

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cites work

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7 January 2021

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

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7 January 2021

Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant

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7 January 2021

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides

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7 January 2021

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

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7 January 2021

Cathepsin B cleavage and release of invariant chain from MHC class II molecules follow a staged pattern

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7 January 2021

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides

1 reference

7 January 2021

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy

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7 January 2021

Mapping functional regions in the lumenal domain of the class II-associated invariant chain

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7 January 2021

Supermotifs enable natural invariant chain-derived peptides to interact with many major histocompatibility complex-class II molecules

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7 January 2021

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

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7 January 2021

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs

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7 January 2021

Binding of an invariant-chain peptide, CLIP, to I-A major histocompatibility complex class II molecules

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7 January 2021

Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding

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7 January 2021

An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules

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7 January 2021

HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

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7 January 2021

Mediation by HLA-DM of dissociation of peptides from HLA-DR.

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7 January 2021

HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading

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7 January 2021

DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide

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7 January 2021

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

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7 January 2021

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

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7 January 2021

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

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7 January 2021

Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen

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7 January 2021

Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1.

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7 January 2021

Selective release of some invariant chain-derived peptides from HLA-DR1 molecules at endosomal pH

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7 January 2021

Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis

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7 January 2021

The human class II MHC protein HLA-DR1 assembles as empty alpha beta heterodimers in the absence of antigenic peptide

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7 January 2021

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

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7 January 2021

T cell recognition of major histocompatibility complex class II complexes with invariant chain processing intermediates

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7 January 2021

Direct observation of disordered regions in the major histocompatibility complex class II-associated invariant chain

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7 January 2021

Invariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1

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7 January 2021

A general model of invariant chain association with class II major histocompatibility complex proteins

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7 January 2021

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

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7 January 2021

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

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7 January 2021

Isolation and characterization of the intracellular MHC class II compartment.

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7 January 2021

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

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7 January 2021

Crystallization of HLA-DR antigens

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7 January 2021

The CCP4 suite: programs for protein crystallography

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7 January 2021

AMoRe: an automated package for molecular replacement

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7 January 2021

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

Conic: a fast renderer for space-filling molecules with shadows

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7 January 2021

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

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7 January 2021

A discussion of the solution for the best rotation to relate two sets of vectors

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7 January 2021

The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC

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7 January 2021