A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease (Q24304932)

GOA release 2020-03-11

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Hans Lehrach

Hans

Lehrach

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9 December 2023

Claire-Anne Gutekunst

22

object named as

Claire-Anne Gutekunst

Claire-Anne

Gutekunst

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9 December 2023

Ulrich Stelzl

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Ulrich

Stelzl

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9 December 2023

Maciej Lalowski

2

Maciej

Lalowski

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9 December 2023

Erich E Wanker

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Erich E

Wanker

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9 December 2023

Bernhard Landwehrmeyer

object named as

Bernhard G Landwehrmeyer

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Bernhard G

Landwehrmeyer

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9 December 2023

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Heike Goehler

Heike

Goehler

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9 December 2023

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Stephanie Waelter

Stephanie

Waelter

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Martin Stroedicke

Martin

Stroedicke

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Uwe Worm

Uwe

Worm

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9 December 2023

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Anja Droege

Anja

Droege

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Christian Haenig

Christian

Haenig

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Claudia Abraham

Claudia

Abraham

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Jaana Suopanki

Jaana

Suopanki

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9 December 2023

Katrin S Lindenberg

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Katrin S

Lindenberg

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Maria Knoblich

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Maria

Knoblich

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Martin Herbst

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Martin

Herbst

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9 December 2023

Eberhard Scherzinger

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Eberhard

Scherzinger

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Bianca Bauer

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Bianca

Bauer

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9 December 2023

Renate Hasenbank

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Renate

Hasenbank

1 reference

9 December 2023

Anja Fritzsche

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Anja

Fritzsche

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9 December 2023

Andreas H Ludewig

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Andreas H

Ludewig

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9 December 2023

Konrad Büssow

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Konrad

Büssow

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9 December 2023

Konrad Buessow

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Sarah H Coleman

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Sarah H

Coleman

1 reference

Intranuclear neuronal inclusions in Huntington's disease and dentatorubral and pallidoluysian atrophy: correlation between the density of inclusions and IT15 CAG triplet repeat length

9 December 2023

language of work or name

English

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publication date

24 September 2004

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published in

Molecular Cell

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volume

15

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issue

6

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page(s)

853-65

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cites work

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Huntingtin-protein interactions and the pathogenesis of Huntington's disease

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Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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Huntingtin-encoded polyglutamine expansions form amyloid-like protein aggregates in vitro and in vivo

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The cell as a collection of protein machines: preparing the next generation of molecular biologists

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Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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Loss of normal huntingtin function: new developments in Huntington's disease research

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Paxillin-ARF GAP signaling and the cytoskeleton

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The hunt for huntingtin function: interaction partners tell many different stories

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Glutamine repeats and neurodegenerative diseases: molecular aspects

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SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates

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Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions

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p95-APP1 links membrane transport to Rac-mediated reorganization of actin

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

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Comparative assessment of large-scale data sets of protein-protein interactions

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Analyzing yeast protein-protein interaction data obtained from different sources

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7 January 2021

Leucine-zipper-mediated homo- and hetero-dimerization of GIT family p95-ARF GTPase-activating protein, PIX-, paxillin-interacting proteins 1 and 2

1 reference

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beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein

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Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity

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GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6

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The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo

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7 January 2021

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

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7 January 2021

Synapse formation is regulated by the signaling adaptor GIT1

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7 January 2021

ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth

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7 January 2021

In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly

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hADA3 is required for p53 activity

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Cell migration: GAPs between membrane traffic and the cytoskeleton

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HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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Network motifs: simple building blocks of complex networks

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Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

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Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

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Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology.

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