Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors (Q24305025)

negative regulation of cell population proliferation

GOA release 2020-03-11

1 reference

LYN proto-oncogene, Src family tyrosine kinase

GOA release 2020-03-11

1 reference

TPO/c-mpl ligand induces tyrosine phosphorylation of multiple cellular proteins including proto-oncogene products, Vav and c-Cbl, and Ras signaling molecules

GOA release 2020-03-11

author name string

Brian J Lannutti

series ordinal

1

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Jonathan G Drachman

series ordinal

2

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language of work or name

English

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publication date

15 May 2004

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published in

Blood

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volume

103

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issue

10

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page(s)

3736-43

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cites work

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Thrombopoietin signal transduction: studies from cell lines and primary cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

The Janus protein tyrosine kinases in hematopoietic cytokine signaling

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Positive and negative roles of the tyrosine kinase Lyn in B cell function

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

1 reference

7 January 2021

Jak2 is essential for signaling through a variety of cytokine receptors

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Thrombopoietin: a pan-hematopoietic cytokine

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

The many faces of Src: multiple functions of a prototypical tyrosine kinase

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

JAKs, STATs and Src kinases in hematopoiesis

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) is promoted by serum stimulation and G2-M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK.

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Thrombopoietin signal transduction requires functional JAK2, not TYK2

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Role of thrombopoietin in hematopoietic stem cell and progenitor regulation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Functional regions of the mouse thrombopoietin receptor cytoplasmic domain: evidence for a critical region which is involved in differentiation and can be complemented by erythropoietin

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Cellular functions regulated by Src family kinases

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Identification of the Src family kinases, Lck and Fgr in platelets. Their tyrosine phosphorylation status and subcellular distribution compared with other Src family members

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Thrombopoietin: the primary regulator of platelet production [see comments]

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Requirement for mitogen-activated protein kinase activation in the response of embryonic stem cell-derived hematopoietic cells to thrombopoietin in vitro

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021

Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation

1 reference

https://api.crossref.org/works/10.1182%2FBLOOD-2003-10-3566

7 January 2021