Regulation of human separase by securin binding and autocleavage (Q24305210)

PTTG1 regulator of sister chromatid separation, securin

GOA release 2020-03-11

1 reference

negative regulation of sister chromatid cohesion

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Jan-Michael Peters

4

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author name string

Irene Waizenegger

1

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Juan F Giménez-Abián

2

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Dominik Wernic

Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis

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language of work or name

English

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publication date

20 August 2002

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published in

Current Biology

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volume

12

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page(s)

1368-78

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issue

16

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cites work

1 reference

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7 January 2021

Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1

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7 January 2021

Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast

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Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p

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7 January 2021

An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast

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7 January 2021

The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene

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7 January 2021

Drosophila separase is required for sister chromatid separation and binds to PIM and THR

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7 January 2021

Separase is required for chromosome segregation during meiosis I in Caenorhabditis elegans

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7 January 2021

Identification of Xenopus SMC protein complexes required for sister chromatid cohesion

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Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes

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7 January 2021

Characterization of vertebrate cohesin complexes and their regulation in prophase

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Cohesin cleavage by separase required for anaphase and cytokinesis in human cells

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7 January 2021

Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase

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7 January 2021

Cut2 proteolysis required for sister-chromatid seperation in fission yeast

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Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

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Degradation of Drosophila PIM regulates sister chromatid separation during mitosis

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Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition.

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7 January 2021

Securin is required for chromosomal stability in human cells

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7 January 2021

Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae

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7 January 2021

Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage

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7 January 2021

Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast

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Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts

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Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division

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7 January 2021

Dual inhibition of sister chromatid separation at metaphase.

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7 January 2021

A yeast gene essential for regulation of spindle pole duplication

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7 January 2021

Requirement for ESP1 in the nuclear division of Saccharomyces cerevisiae

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7 January 2021

The dual mechanism of separase regulation by securin

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7 January 2021

Structural basis for the inhibition of caspase-3 by XIAP

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7 January 2021

Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes.

1 reference

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7 January 2021

Degradation of a cohesin subunit by the N-end rule pathway is essential for chromosome stability

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7 January 2021

The N-end rule pathway of protein degradation

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7 January 2021

Separase: a conserved protease separating more than just sisters

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7 January 2021