Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein (Q24305403)

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Jianming Chen

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Hong Xin

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Divaker Choubey

Molecular genetics of prostate cancer.

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language of work or name

English

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publication date

6 March 2006

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published in

FEBS Letters

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volume

580

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issue

6

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page(s)

1659-64

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cites work

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Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis

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Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis.

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Androgens regulate the immune/inflammatory response and cell survival pathways in rat ventral prostate epithelial cells

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Interaction between the androgen receptor and RNase L mediates a cross-talk between the interferon and androgen signaling pathways

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Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence

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Role of IFI 16 in cellular senescence of human fibroblasts

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A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway

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Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16

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Reduction of wild type p53 function confers a hormone resistant phenotype on LNCaP prostate cancer cells

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Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21(CIP1) levels in androgen-independent human prostate cancer cells

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Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16

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FXXLF and WXXLF sequences mediate the NH2-terminal interaction with the ligand binding domain of the androgen receptor

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Inhibition of E2F-mediated transcription by p202

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Tumor suppressor genes

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Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor

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c-Jun can mediate androgen receptor-induced transactivation

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Transcription and growth regulatory functions of the HIN-200 family of proteins

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