Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40 (Q24307191)

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Yanhui Xu

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Qing Bao

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Yongna Xing

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Zhu Li

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Zheng Lin

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Jeffry B Stock

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Philip D Jeffrey

Nature Structural & Molecular Biology

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language of work or name

English

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publication date

June 2007

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published in

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volume

14

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issue

6

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page(s)

527-34

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cites work

Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells

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Identification of binding sites on the regulatory A subunit of protein phosphatase 2A for the catalytic C subunit and for tumor antigens of simian virus 40 and polyomavirus

21 January 2018

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Dephosphorylation of simian virus 40 large-T antigen and p53 protein by protein phosphatase 2A: inhibition by small-t antigen

21 January 2018

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Control of protein phosphatase 2A by simian virus 40 small-t antigen

21 January 2018

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The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain.

21 January 2018

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

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Protein phosphatase 2A: a panoply of enzymes.

31 March 2020

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alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure

31 March 2020

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Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A.

31 March 2020

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Molecular cloning and sequence analysis of the catalytic subunit of bovine type 2A protein phosphatase

31 March 2020

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Human liver phosphatase 2A: cDNA and amino acid sequence of two catalytic subunit isotypes

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WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A

31 March 2020

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PP2A: the expected tumor suppressor

31 March 2020

1 reference

Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A.

31 March 2020

1 reference

Association of protein phosphatase 2A with polyoma virus medium tumor antigen

31 March 2020

1 reference

The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.

31 March 2020

1 reference

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

31 March 2020

1 reference

Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A

31 March 2020

1 reference

Phosphatase 2A associated with polyomavirus small-T or middle-T antigen is an okadaic acid-sensitive tyrosyl phosphatase

31 March 2020

1 reference

PP2A fulfills its promises as tumor suppressor: which subunits are important?

31 March 2020

1 reference

Identification of specific PP2A complexes involved in human cell transformation

31 March 2020

1 reference

Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins

31 March 2020

1 reference

Structure of the protein phosphatase 2A holoenzyme

31 March 2020

1 reference

Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme

31 March 2020

1 reference

The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs

31 March 2020

1 reference

Protein structure comparison by alignment of distance matrices

31 March 2020

1 reference

Improved methods for building protein models in electron density maps and the location of errors in these models

31 March 2020

1 reference

Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen

31 March 2020

1 reference

Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes

31 March 2020

1 reference

The phosphotyrosyl phosphatase activator of protein phosphatase 2A. A novel purification method, immunological and enzymic characterization.

31 March 2020

1 reference

Structure and mechanism of the phosphotyrosyl phosphatase activator

31 March 2020

1 reference

Kinomics: methods for deciphering the kinome

31 March 2020

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Processing of X-ray diffraction data collected in oscillation mode

31 March 2020

1 reference

Likelihood-enhanced fast translation functions

31 March 2020

1 reference

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

31 March 2020

1 reference

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

31 March 2020

1 reference

Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Simian virus 40 small-t antigen binds two zinc ions.

1 reference